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Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans

Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG detoxifying system Glyoxalase 1, led to limited MG elevation but significantly elevated aldehyde dehydrogenases (ALDH) activity and aldh3a1 expression, suggesting the compe...

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Detalles Bibliográficos
Autores principales:	Lou, Bowen, Boger, Mike, Bennewitz, Katrin, Sticht, Carsten, Kopf, Stefan, Morgenstern, Jakob, Fleming, Thomas, Hell, Rüdiger, Yuan, Zuyi, Nawroth, Peter Paul, Kroll, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519378/ https://www.ncbi.nlm.nih.gov/pubmed/32980661 http://dx.doi.org/10.1016/j.redox.2020.101723

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