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Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519463/ https://www.ncbi.nlm.nih.gov/pubmed/33014057 http://dx.doi.org/10.1155/2020/8659802 |
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author | Afshari, Amir R. Mollazadeh, Hamid Sahebkar, Amirhossein |
author_facet | Afshari, Amir R. Mollazadeh, Hamid Sahebkar, Amirhossein |
author_sort | Afshari, Amir R. |
collection | PubMed |
description | One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM. |
format | Online Article Text |
id | pubmed-7519463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75194632020-10-02 Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic Afshari, Amir R. Mollazadeh, Hamid Sahebkar, Amirhossein J Oncol Review Article One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM. Hindawi 2020-09-17 /pmc/articles/PMC7519463/ /pubmed/33014057 http://dx.doi.org/10.1155/2020/8659802 Text en Copyright © 2020 Amir R. Afshari et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Afshari, Amir R. Mollazadeh, Hamid Sahebkar, Amirhossein Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic |
title | Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic |
title_full | Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic |
title_fullStr | Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic |
title_full_unstemmed | Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic |
title_short | Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic |
title_sort | minocycline in treating glioblastoma multiforme: far beyond a conventional antibiotic |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519463/ https://www.ncbi.nlm.nih.gov/pubmed/33014057 http://dx.doi.org/10.1155/2020/8659802 |
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