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Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic

One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic a...

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Detalles Bibliográficos
Autores principales: Afshari, Amir R., Mollazadeh, Hamid, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519463/
https://www.ncbi.nlm.nih.gov/pubmed/33014057
http://dx.doi.org/10.1155/2020/8659802
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author Afshari, Amir R.
Mollazadeh, Hamid
Sahebkar, Amirhossein
author_facet Afshari, Amir R.
Mollazadeh, Hamid
Sahebkar, Amirhossein
author_sort Afshari, Amir R.
collection PubMed
description One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.
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spelling pubmed-75194632020-10-02 Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic Afshari, Amir R. Mollazadeh, Hamid Sahebkar, Amirhossein J Oncol Review Article One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM. Hindawi 2020-09-17 /pmc/articles/PMC7519463/ /pubmed/33014057 http://dx.doi.org/10.1155/2020/8659802 Text en Copyright © 2020 Amir R. Afshari et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Afshari, Amir R.
Mollazadeh, Hamid
Sahebkar, Amirhossein
Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
title Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
title_full Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
title_fullStr Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
title_full_unstemmed Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
title_short Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic
title_sort minocycline in treating glioblastoma multiforme: far beyond a conventional antibiotic
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519463/
https://www.ncbi.nlm.nih.gov/pubmed/33014057
http://dx.doi.org/10.1155/2020/8659802
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