Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 diabetes the destructive effects of metabolic stres...

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Detalles Bibliográficos
Autores principales: Hewawasam, Nirun V., Lhaf, Fadel, Taylor, Henry A., Viloria, Katrina, Austin, Amazon, King, Aileen, Jones, Peter, Jones, Lucy, Turner, Mark D., Hill, Natasha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519639/
https://www.ncbi.nlm.nih.gov/pubmed/32978479
http://dx.doi.org/10.1038/s41598-020-72939-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519639/
https://www.ncbi.nlm.nih.gov/pubmed/32978479
http://dx.doi.org/10.1038/s41598-020-72939-y

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