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Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes

Motor symptoms of Parkinson’s disease (PD) occur unilaterally and progress with asymmetry, while progressive supranuclear palsy (PSP) and multiple system atrophy of the parkinsonism subtype (MSA-P) lack this tendency. We assessed the laterality of specific binding ratios (SBRs) on dopamine transport...

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Autores principales: Shigekiyo, Taro, Arawaka, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519659/
https://www.ncbi.nlm.nih.gov/pubmed/32978422
http://dx.doi.org/10.1038/s41598-020-72321-y
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author Shigekiyo, Taro
Arawaka, Shigeki
author_facet Shigekiyo, Taro
Arawaka, Shigeki
author_sort Shigekiyo, Taro
collection PubMed
description Motor symptoms of Parkinson’s disease (PD) occur unilaterally and progress with asymmetry, while progressive supranuclear palsy (PSP) and multiple system atrophy of the parkinsonism subtype (MSA-P) lack this tendency. We assessed the laterality of specific binding ratios (SBRs) on dopamine transporter single-photon emission computed tomography (DAT-SPECT) for the differential diagnosis of these diseases in 311 PD, 33 PSP, 20 MSA-P, and 137 control patients. The average SBR in PD was higher than that in PSP (P = 0.035). Compared with Hoehn–Yahr (HY) stages, the average SBR in PD with HY stage I was only higher than that in PSP (P < 0.001). SBR laterality in PD with HY stage I was significantly higher than that in PSP (P = 0.001). This difference was not observed in PD with HY stage II. The average and laterality of SBRs in MSA-P were similar to those in PD and PSP. The asymmetry indices were similar among PD, PSP, and MSA-P. These data suggest that PSP shows a pattern of SBRs different from that in PD, attributed to HY stage I in PD. The limited usefulness of DAT-SPECT may be explained by the low discrimination between PD with bilateral motor symptoms and PSP.
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spelling pubmed-75196592020-09-29 Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes Shigekiyo, Taro Arawaka, Shigeki Sci Rep Article Motor symptoms of Parkinson’s disease (PD) occur unilaterally and progress with asymmetry, while progressive supranuclear palsy (PSP) and multiple system atrophy of the parkinsonism subtype (MSA-P) lack this tendency. We assessed the laterality of specific binding ratios (SBRs) on dopamine transporter single-photon emission computed tomography (DAT-SPECT) for the differential diagnosis of these diseases in 311 PD, 33 PSP, 20 MSA-P, and 137 control patients. The average SBR in PD was higher than that in PSP (P = 0.035). Compared with Hoehn–Yahr (HY) stages, the average SBR in PD with HY stage I was only higher than that in PSP (P < 0.001). SBR laterality in PD with HY stage I was significantly higher than that in PSP (P = 0.001). This difference was not observed in PD with HY stage II. The average and laterality of SBRs in MSA-P were similar to those in PD and PSP. The asymmetry indices were similar among PD, PSP, and MSA-P. These data suggest that PSP shows a pattern of SBRs different from that in PD, attributed to HY stage I in PD. The limited usefulness of DAT-SPECT may be explained by the low discrimination between PD with bilateral motor symptoms and PSP. Nature Publishing Group UK 2020-09-25 /pmc/articles/PMC7519659/ /pubmed/32978422 http://dx.doi.org/10.1038/s41598-020-72321-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shigekiyo, Taro
Arawaka, Shigeki
Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes
title Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes
title_full Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes
title_fullStr Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes
title_full_unstemmed Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes
title_short Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes
title_sort laterality of specific binding ratios on dat-spect for differential diagnosis of degenerative parkinsonian syndromes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519659/
https://www.ncbi.nlm.nih.gov/pubmed/32978422
http://dx.doi.org/10.1038/s41598-020-72321-y
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