pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model

Huntington disease (HD) is a hereditary neurodegenerative disorder caused by mutant huntingtin (mHTT). Phosphorylation at serine-421 (pS421) of mHTT has been shown to be neuroprotective in cellular and rodent models. However, the genetic context of these models differs from that of HD patients. Here...

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Detalles Bibliográficos
Autores principales: Xu, Xiaohong, Ng, Bryan, Sim, Bernice, Radulescu, Carola I., Yusof, Nur Amirah Binte Mohammad, Goh, Wah Ing, Lin, Shuping, Lim, John Soon Yew, Cha, Yoonjeong, Kusko, Rebecca, Kay, Chris, Ratovitski, Tamara, Ross, Christopher, Hayden, Michael R., Wright, Graham, Pouladi, Mahmoud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519662/
https://www.ncbi.nlm.nih.gov/pubmed/32978366
http://dx.doi.org/10.1038/s41419-020-02983-z

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