Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor

Single-cell whole-exome sequencing (scWES) is a powerful approach for deciphering intratumor heterogeneity and identifying cancer drivers. So far, however, simultaneous analysis of single nucleotide variants (SNVs) and copy number variations (CNVs) of a single cell has been challenging. By analyzing...

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Detalles Bibliográficos
Autores principales: Liu, Jianlin, Adhav, Ragini, Miao, Kai, Su, Sek Man, Mo, Lihua, Chan, Un In, Zhang, Xin, Xu, Jun, Li, Jianjie, Shu, Xiaodong, Zeng, Jianming, Zhang, Xu, Lyu, Xueying, Pardeshi, Lakhansing, Tan, Kaeling, Sun, Heng, Wong, Koon Ho, Deng, Chuxia, Xu, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519681/
https://www.ncbi.nlm.nih.gov/pubmed/32978388
http://dx.doi.org/10.1038/s41467-020-18637-9

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