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Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era

Lockdown is one of the drastic measures implemented by governments to curtail the spread of the Covid-19 pandemic and save lives. However, it has caused unprecedented damages to the economy. This paper provides a quantitative approach to assess the impact of a gradual, post-lockdown context concerni...

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Autores principales: Tchepmo Djomegni, Patrick M, Haggar, M.S. Daoussa, Adigo, Wubetea T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. on behalf of Faculty of Engineering, Alexandria University. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519729/
http://dx.doi.org/10.1016/j.aej.2020.09.028
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author Tchepmo Djomegni, Patrick M
Haggar, M.S. Daoussa
Adigo, Wubetea T.
author_facet Tchepmo Djomegni, Patrick M
Haggar, M.S. Daoussa
Adigo, Wubetea T.
author_sort Tchepmo Djomegni, Patrick M
collection PubMed
description Lockdown is one of the drastic measures implemented by governments to curtail the spread of the Covid-19 pandemic and save lives. However, it has caused unprecedented damages to the economy. This paper provides a quantitative approach to assess the impact of a gradual, post-lockdown context concerning the spread of the disease. We propose to create a special class of individuals called “protected” who are risk-free to be infected. Such individuals could also be the vaccinated when an effective vaccine will be available. We developed a mathematical epidemic model for Covid-19 which describes the interactions between susceptible and infected individuals. We investigate the various and optimal strategies to curtail the spread of the infection at a minimum cost. As a case study on South Africa, the sensitivity analysis shows that investing on the special class “protected” is a better approach to reducing new secondary infections as opposed to reducing the contact rate between susceptible and infected individuals, or having more recovered patients. The simulations reveal that the peak could be reached in September 2020. This is consistent with the projection of the South African government as the winter season is expected to be over in mid August. Moreover, if 1 out of 1000 susceptible (cumulatively) join the special class, we project a maximum of 400,000 active cases. The number of infected and deaths could drastically increase as the proportion of individuals joining the special class decreases.
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spelling pubmed-75197292020-09-28 Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era Tchepmo Djomegni, Patrick M Haggar, M.S. Daoussa Adigo, Wubetea T. Alexandria Engineering Journal Article Lockdown is one of the drastic measures implemented by governments to curtail the spread of the Covid-19 pandemic and save lives. However, it has caused unprecedented damages to the economy. This paper provides a quantitative approach to assess the impact of a gradual, post-lockdown context concerning the spread of the disease. We propose to create a special class of individuals called “protected” who are risk-free to be infected. Such individuals could also be the vaccinated when an effective vaccine will be available. We developed a mathematical epidemic model for Covid-19 which describes the interactions between susceptible and infected individuals. We investigate the various and optimal strategies to curtail the spread of the infection at a minimum cost. As a case study on South Africa, the sensitivity analysis shows that investing on the special class “protected” is a better approach to reducing new secondary infections as opposed to reducing the contact rate between susceptible and infected individuals, or having more recovered patients. The simulations reveal that the peak could be reached in September 2020. This is consistent with the projection of the South African government as the winter season is expected to be over in mid August. Moreover, if 1 out of 1000 susceptible (cumulatively) join the special class, we project a maximum of 400,000 active cases. The number of infected and deaths could drastically increase as the proportion of individuals joining the special class decreases. The Authors. Published by Elsevier B.V. on behalf of Faculty of Engineering, Alexandria University. 2021-02 2020-09-26 /pmc/articles/PMC7519729/ http://dx.doi.org/10.1016/j.aej.2020.09.028 Text en © 2020 The Authors. Published by Elsevier B.V. on behalf of Faculty of Engineering, Alexandria University. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tchepmo Djomegni, Patrick M
Haggar, M.S. Daoussa
Adigo, Wubetea T.
Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era
title Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era
title_full Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era
title_fullStr Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era
title_full_unstemmed Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era
title_short Mathematical model for Covid-19 with “protected susceptible” in the post-lockdown era
title_sort mathematical model for covid-19 with “protected susceptible” in the post-lockdown era
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519729/
http://dx.doi.org/10.1016/j.aej.2020.09.028
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