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Mesenchymal stem cells as a multimodal treatment for nervous system diseases

Neurological disorders are a massive challenge for modern medicine. Apart from the fact that this group of diseases is the second leading cause of death worldwide, the majority of patients have no access to any possible effective and standardized treatment after being diagnosed, leaving them and the...

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Autores principales: Badyra, Bogna, Sułkowski, Maciej, Milczarek, Olga, Majka, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519763/
https://www.ncbi.nlm.nih.gov/pubmed/32573961
http://dx.doi.org/10.1002/sctm.19-0430
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author Badyra, Bogna
Sułkowski, Maciej
Milczarek, Olga
Majka, Marcin
author_facet Badyra, Bogna
Sułkowski, Maciej
Milczarek, Olga
Majka, Marcin
author_sort Badyra, Bogna
collection PubMed
description Neurological disorders are a massive challenge for modern medicine. Apart from the fact that this group of diseases is the second leading cause of death worldwide, the majority of patients have no access to any possible effective and standardized treatment after being diagnosed, leaving them and their families helpless. This is the reason why such great emphasis is being placed on the development of new, more effective methods to treat neurological patients. Regenerative medicine opens new therapeutic approaches in neurology, including the use of cell‐based therapies. In this review, we focus on summarizing one of the cell sources that can be applied as a multimodal treatment tool to overcome the complex issue of neurodegeneration—mesenchymal stem cells (MSCs). Apart from the highly proven safety of this approach, beneficial effects connected to this type of treatment have been observed. This review presents modes of action of MSCs, explained on the basis of data from vast in vitro and preclinical studies, and we summarize the effects of using these cells in clinical trial settings. Finally, we stress what improvements have already been made to clarify the exact mechanism of MSCs action, and we discuss potential ways to improve the introduction of MSC‐based therapies in clinics. In summary, we propose that more insightful and methodical optimization, by combining careful preparation and administration, can enable use of multimodal MSCs as an effective, tailored cell therapy suited to specific neurological disorders.
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spelling pubmed-75197632020-09-30 Mesenchymal stem cells as a multimodal treatment for nervous system diseases Badyra, Bogna Sułkowski, Maciej Milczarek, Olga Majka, Marcin Stem Cells Transl Med Concise Reviews Neurological disorders are a massive challenge for modern medicine. Apart from the fact that this group of diseases is the second leading cause of death worldwide, the majority of patients have no access to any possible effective and standardized treatment after being diagnosed, leaving them and their families helpless. This is the reason why such great emphasis is being placed on the development of new, more effective methods to treat neurological patients. Regenerative medicine opens new therapeutic approaches in neurology, including the use of cell‐based therapies. In this review, we focus on summarizing one of the cell sources that can be applied as a multimodal treatment tool to overcome the complex issue of neurodegeneration—mesenchymal stem cells (MSCs). Apart from the highly proven safety of this approach, beneficial effects connected to this type of treatment have been observed. This review presents modes of action of MSCs, explained on the basis of data from vast in vitro and preclinical studies, and we summarize the effects of using these cells in clinical trial settings. Finally, we stress what improvements have already been made to clarify the exact mechanism of MSCs action, and we discuss potential ways to improve the introduction of MSC‐based therapies in clinics. In summary, we propose that more insightful and methodical optimization, by combining careful preparation and administration, can enable use of multimodal MSCs as an effective, tailored cell therapy suited to specific neurological disorders. John Wiley & Sons, Inc. 2020-06-23 /pmc/articles/PMC7519763/ /pubmed/32573961 http://dx.doi.org/10.1002/sctm.19-0430 Text en © 2020 The Authors. stem cells translational medicine published by Wiley Periodicals LLC on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Concise Reviews
Badyra, Bogna
Sułkowski, Maciej
Milczarek, Olga
Majka, Marcin
Mesenchymal stem cells as a multimodal treatment for nervous system diseases
title Mesenchymal stem cells as a multimodal treatment for nervous system diseases
title_full Mesenchymal stem cells as a multimodal treatment for nervous system diseases
title_fullStr Mesenchymal stem cells as a multimodal treatment for nervous system diseases
title_full_unstemmed Mesenchymal stem cells as a multimodal treatment for nervous system diseases
title_short Mesenchymal stem cells as a multimodal treatment for nervous system diseases
title_sort mesenchymal stem cells as a multimodal treatment for nervous system diseases
topic Concise Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519763/
https://www.ncbi.nlm.nih.gov/pubmed/32573961
http://dx.doi.org/10.1002/sctm.19-0430
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