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Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments
Changes in body composition are associated with poor outcomes in cancer patients including hepatocellular carcinoma (HCC). Sarcopenia, defined as the loss of skeletal muscle mass, quality and function, has been associated with a higher rate of complications and recurrences in patients with cirrhosis...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519899/ https://www.ncbi.nlm.nih.gov/pubmed/32748172 http://dx.doi.org/10.1007/s00535-020-01711-w |
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author | Marasco, Giovanni Serenari, Matteo Renzulli, Matteo Alemanni, Luigina Vanessa Rossini, Benedetta Pettinari, Irene Dajti, Elton Ravaioli, Federico Golfieri, Rita Cescon, Matteo Festi, Davide Colecchia, Antonio |
author_facet | Marasco, Giovanni Serenari, Matteo Renzulli, Matteo Alemanni, Luigina Vanessa Rossini, Benedetta Pettinari, Irene Dajti, Elton Ravaioli, Federico Golfieri, Rita Cescon, Matteo Festi, Davide Colecchia, Antonio |
author_sort | Marasco, Giovanni |
collection | PubMed |
description | Changes in body composition are associated with poor outcomes in cancer patients including hepatocellular carcinoma (HCC). Sarcopenia, defined as the loss of skeletal muscle mass, quality and function, has been associated with a higher rate of complications and recurrences in patients with cirrhosis and HCC. The assessment of patient general status before HCC treatment, including the presence of sarcopenia, is a key-point for achieving therapy tolerability and to avoid short- and long-term complications leading to poor patients’ survival. Thus, we aimed to review the current literature evaluating the role of sarcopenia assessment related to HCC treatments and to critically provide the clinicians with the most recent and valuable evidence. As a result, sarcopenia can be predictive of poor outcomes in patients undergoing liver resection, transplantation and systemic therapies, offering the chance to clinicians to improve the muscular status of these patients, especially those with high-grade sarcopenia at high risk of mortality. Further studies are needed to clarify the predictive value of sarcopenia in other HCC treatment settings and to evaluate its role as an additional staging tool for identifying the most appropriate treatment. Besides, interventional studies aiming at increasing the skeletal muscle mass for reducing complications and increasing the survival in patients with HCC are needed. |
format | Online Article Text |
id | pubmed-7519899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-75198992020-10-13 Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments Marasco, Giovanni Serenari, Matteo Renzulli, Matteo Alemanni, Luigina Vanessa Rossini, Benedetta Pettinari, Irene Dajti, Elton Ravaioli, Federico Golfieri, Rita Cescon, Matteo Festi, Davide Colecchia, Antonio J Gastroenterol Review Changes in body composition are associated with poor outcomes in cancer patients including hepatocellular carcinoma (HCC). Sarcopenia, defined as the loss of skeletal muscle mass, quality and function, has been associated with a higher rate of complications and recurrences in patients with cirrhosis and HCC. The assessment of patient general status before HCC treatment, including the presence of sarcopenia, is a key-point for achieving therapy tolerability and to avoid short- and long-term complications leading to poor patients’ survival. Thus, we aimed to review the current literature evaluating the role of sarcopenia assessment related to HCC treatments and to critically provide the clinicians with the most recent and valuable evidence. As a result, sarcopenia can be predictive of poor outcomes in patients undergoing liver resection, transplantation and systemic therapies, offering the chance to clinicians to improve the muscular status of these patients, especially those with high-grade sarcopenia at high risk of mortality. Further studies are needed to clarify the predictive value of sarcopenia in other HCC treatment settings and to evaluate its role as an additional staging tool for identifying the most appropriate treatment. Besides, interventional studies aiming at increasing the skeletal muscle mass for reducing complications and increasing the survival in patients with HCC are needed. Springer Singapore 2020-08-03 2020 /pmc/articles/PMC7519899/ /pubmed/32748172 http://dx.doi.org/10.1007/s00535-020-01711-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Marasco, Giovanni Serenari, Matteo Renzulli, Matteo Alemanni, Luigina Vanessa Rossini, Benedetta Pettinari, Irene Dajti, Elton Ravaioli, Federico Golfieri, Rita Cescon, Matteo Festi, Davide Colecchia, Antonio Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
title | Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
title_full | Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
title_fullStr | Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
title_full_unstemmed | Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
title_short | Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
title_sort | clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519899/ https://www.ncbi.nlm.nih.gov/pubmed/32748172 http://dx.doi.org/10.1007/s00535-020-01711-w |
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