Lysine-specific histone demethylase 1A (LSD1) in cervical cancer

PURPOSE: Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use. METHODS: Tumor samples of 250 cervical cancer patients were...

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Autores principales: Beilner, Daniel, Kuhn, Christina, Kost, Bernd P., Jückstock, Julia, Mayr, Doris, Schmoeckel, Elisa, Dannecker, Christian, Mahner, Sven, Jeschke, Udo, Heidegger, Helene Hildegard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article – Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519903/
https://www.ncbi.nlm.nih.gov/pubmed/32725356
http://dx.doi.org/10.1007/s00432-020-03338-z
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author Beilner, Daniel
Kuhn, Christina
Kost, Bernd P.
Jückstock, Julia
Mayr, Doris
Schmoeckel, Elisa
Dannecker, Christian
Mahner, Sven
Jeschke, Udo
Heidegger, Helene Hildegard
author_facet Beilner, Daniel
Kuhn, Christina
Kost, Bernd P.
Jückstock, Julia
Mayr, Doris
Schmoeckel, Elisa
Dannecker, Christian
Mahner, Sven
Jeschke, Udo
Heidegger, Helene Hildegard
author_sort Beilner, Daniel
collection PubMed
description PURPOSE: Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use. METHODS: Tumor samples of 250 cervical cancer patients were immunochemically stained and evaluated based on Immunoreactive Score. Results were statistically analyzed for clinical and pathological parameters. RESULTS: Our patient collective showed a disadvantage for 10-year survival for patients with a strong expression of LSD1 in the cytoplasm of cervical cancer cells. The results of the correlational analysis further revealed a negative correlation of LSD1 to G-protein coupled estrogen receptor (GPER). CONCLUSIONS: Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations.
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spelling pubmed-75199032020-10-13 Lysine-specific histone demethylase 1A (LSD1) in cervical cancer Beilner, Daniel Kuhn, Christina Kost, Bernd P. Jückstock, Julia Mayr, Doris Schmoeckel, Elisa Dannecker, Christian Mahner, Sven Jeschke, Udo Heidegger, Helene Hildegard J Cancer Res Clin Oncol Original Article – Cancer Research PURPOSE: Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use. METHODS: Tumor samples of 250 cervical cancer patients were immunochemically stained and evaluated based on Immunoreactive Score. Results were statistically analyzed for clinical and pathological parameters. RESULTS: Our patient collective showed a disadvantage for 10-year survival for patients with a strong expression of LSD1 in the cytoplasm of cervical cancer cells. The results of the correlational analysis further revealed a negative correlation of LSD1 to G-protein coupled estrogen receptor (GPER). CONCLUSIONS: Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations. Springer Berlin Heidelberg 2020-07-28 2020 /pmc/articles/PMC7519903/ /pubmed/32725356 http://dx.doi.org/10.1007/s00432-020-03338-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article – Cancer Research
Beilner, Daniel
Kuhn, Christina
Kost, Bernd P.
Jückstock, Julia
Mayr, Doris
Schmoeckel, Elisa
Dannecker, Christian
Mahner, Sven
Jeschke, Udo
Heidegger, Helene Hildegard
Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
title Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
title_full Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
title_fullStr Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
title_full_unstemmed Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
title_short Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
title_sort lysine-specific histone demethylase 1a (lsd1) in cervical cancer
topic Original Article – Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519903/
https://www.ncbi.nlm.nih.gov/pubmed/32725356
http://dx.doi.org/10.1007/s00432-020-03338-z
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