Cargando…

LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway

AIMS: We aimed to investigate whether LCZ696 protects against pathological cardiac hypertrophy by regulating the Sirt3/MnSOD pathway. METHODS: In vivo, we established a transverse aortic constriction animal model to establish pressure overload-induced heart failure. Subsequently, the mice were given...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Shi, Lu, Xiao-feng, Qi, Yi-ding, Li, Jing, Xu, Juan, Yuan, Tian-you, Wu, Xiao-yu, Ding, Yu, Li, Wen-hua, Zhou, Gen-qing, Wei, Yong, Li, Jun, Chen, Song-wen, Liu, Shao-wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519988/ https://www.ncbi.nlm.nih.gov/pubmed/33014281 http://dx.doi.org/10.1155/2020/9815039

Ejemplares similares

LCZ696 ameliorates lipopolysaccharide-induced endothelial injury
por: Gao, Aihong, et al.
Publicado: (2021)

LCZ696 ameliorates doxorubicin-induced cardiomyocyte toxicity in rats
por: Miyoshi, Toru, et al.
Publicado: (2022)

Safety of the neprilysin/renin-angiotensin system inhibitor LCZ696
por: Li, Bo, et al.
Publicado: (2017)

Tetramerization Reinforces the Dimer Interface of MnSOD
por: Sheng, Yuewei, et al.
Publicado: (2013)

A Meta-Analysis on the Effect and Safety of LCZ696 in the Treatment of Hypertension
por: Zheng, Li, et al.
Publicado: (2021)

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells
por: Fan, Jhen-Jia, et al.
Publicado: (2019)

Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism
por: Wang, Dong Mei, et al.
Publicado: (2022)

Modeling and phylogeny analysis of bread wheat MnSOD
por: Sheoran, Sonia, et al.
Publicado: (2011)

Modulation of MnSOD in Cancer:Epidemiological and Experimental Evidence
por: Kim, Aekyong
Publicado: (2010)

The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD
por: Borrelli, Antonella, et al.
Publicado: (2014)

Association of MnSOD AA Genotype with the Progression of Prostate Cancer
por: Iguchi, Taro, et al.
Publicado: (2015)

The structure–function relationships and physiological roles of MnSOD mutants
por: Bonetta Valentino, Rosalin
Publicado: (2022)

Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
por: Lee, Chang-Yu, et al.
Publicado: (2019)

Significance of AtMTM1 and AtMTM2 for Mitochondrial MnSOD Activation in Arabidopsis
por: Hu, Shu-Hsuan, et al.
Publicado: (2021)

LCZ696 Ameliorates Isoproterenol-Induced Acute Heart Failure in Rats by Activating the Nrf2 Signaling Pathway
por: Hou, Min, et al.
Publicado: (2022)

AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD
por: Brandauer, Josef, et al.
Publicado: (2015)

No Association of Four Candidate Genetic Variants in MnSOD and SYNIII with Parkinson's Disease in Two Chinese Populations
por: Yu, Wen Juan, et al.
Publicado: (2014)

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management
por: Bellot, Gregory Lucien, et al.
Publicado: (2018)

Cardioprotective Effects of LCZ696 (Sacubitril/Valsartan) After Experimental Acute Myocardial Infarction
por: Ishii, Masanobu, et al.
Publicado: (2017)

Effect and safety of LCZ696 in the treatment of hypertension: A meta-analysis of 9 RCT studies
por: Li, Qiongqiong, et al.
Publicado: (2019)

Preferential selection of MnSOD transcripts in proliferating normal and cancer cells
por: Chaudhuri, Leena, et al.
Publicado: (2011)

Aging, MnSOD, and hormesis mechanisms converge on liver mUPR
por: Shen, Jie, et al.
Publicado: (2013)

HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD
por: Hou, Qian, et al.
Publicado: (2018)

LCZ696, an Angiotensin Receptor-Neprilysin Inhibitor, Improves Cardiac Hypertrophy and Fibrosis and Cardiac Lymphatic Remodeling in Transverse Aortic Constriction Model Mice
por: Ge, Qing, et al.
Publicado: (2020)

The protective effect of LCZ696 in coxsackievirus B3‐induced acute viral myocarditis mice
por: Jing, Xu, et al.
Publicado: (2022)

Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol
por: Ni, Yajuan, et al.
Publicado: (2020)

A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure
por: McMurray, John, et al.
Publicado: (2015)

PARADIGM-HF trial: will LCZ696 change the current treatment of systolic heart failure?
por: Kaplinsky, Edgardo
Publicado: (2015)

LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model
por: Chang, Po-Cheng, et al.
Publicado: (2019)

High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin
por: Fu, Afu, et al.
Publicado: (2016)

HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells
por: Zhang, Yanyan, et al.
Publicado: (2018)

The level of MnSOD is directly correlated with grade of brain tumours of neuroepithelial origin.
por: Landriscina, M., et al.
Publicado: (1996)

MnSOD Upregulation Induces Autophagic Programmed Cell Death in Senescent Keratinocytes
por: Deruy, Emeric, et al.
Publicado: (2010)

Roles of the Two-MnSOD System of Stenotrophomonas maltophilia in the Alleviation of Superoxide Stress
por: Jair, Herng-Woei, et al.
Publicado: (2019)

LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure and hypertension
por: Lefkowitz, Martin P
Publicado: (2011)

The effect of LCZ696 (sacubitril/valsartan) on amyloid‐β concentrations in cerebrospinal fluid in healthy subjects
por: Langenickel, Thomas H., et al.
Publicado: (2016)

Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF
por: Jhund, Pardeep S., et al.
Publicado: (2015)

Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization
por: Langenickel, Thomas H., et al.
Publicado: (2016)

MnSOD(tg) Mice Control Myocardial Inflammatory and Oxidative Stress and Remodeling Responses Elicited in Chronic Chagas Disease
por: Dhiman, Monisha, et al.
Publicado: (2013)

Transcriptomic characterization of the enzymatic antioxidants FeSOD, MnSOD, APX and KatG in the dinoflagellate genus Symbiodinium
por: Krueger, Thomas, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_iq8nas3ad5ak10epnl28u0i5h5