The authors’ response

In response to comments raised, we acknowledge the shortcomings of our study. It is a small study. However, it is a pilot study, which is not meant to create generalizable data, rather to explore new potential directions. To this end, our conclusions were clearly supported by the results. We demonst...

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Detalles Bibliográficos
Autores principales: Sadan, Ofer, Samuels, Owen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520020/
https://www.ncbi.nlm.nih.gov/pubmed/32999726
http://dx.doi.org/10.1186/s40560-020-00493-w
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author Sadan, Ofer
Samuels, Owen
author_facet Sadan, Ofer
Samuels, Owen
author_sort Sadan, Ofer
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description In response to comments raised, we acknowledge the shortcomings of our study. It is a small study. However, it is a pilot study, which is not meant to create generalizable data, rather to explore new potential directions. To this end, our conclusions were clearly supported by the results. We demonstrated that administration of 16.4% NaCl/Na-acetate solution was feasible, safe, and was associated with lower rates of AKI. We share the call that large RCTs are required to follow this pilot study and hope that our data will stimulate the ongoing discussion regarding the role of chloride in AKI mechanism.
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spelling pubmed-75200202020-09-29 The authors’ response Sadan, Ofer Samuels, Owen J Intensive Care Commentary In response to comments raised, we acknowledge the shortcomings of our study. It is a small study. However, it is a pilot study, which is not meant to create generalizable data, rather to explore new potential directions. To this end, our conclusions were clearly supported by the results. We demonstrated that administration of 16.4% NaCl/Na-acetate solution was feasible, safe, and was associated with lower rates of AKI. We share the call that large RCTs are required to follow this pilot study and hope that our data will stimulate the ongoing discussion regarding the role of chloride in AKI mechanism. BioMed Central 2020-09-26 /pmc/articles/PMC7520020/ /pubmed/32999726 http://dx.doi.org/10.1186/s40560-020-00493-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Sadan, Ofer
Samuels, Owen
The authors’ response
title The authors’ response
title_full The authors’ response
title_fullStr The authors’ response
title_full_unstemmed The authors’ response
title_short The authors’ response
title_sort authors’ response
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520020/
https://www.ncbi.nlm.nih.gov/pubmed/32999726
http://dx.doi.org/10.1186/s40560-020-00493-w
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