Presenilin1 familial Alzheimer disease mutants inactivate EFNB1- and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-aspartate receptor

Excitotoxicity is thought to play key roles in brain neurodegeneration and stroke. Here we show that neuroprotection against excitotoxicity by trophic factors EFNB1 and brain-derived neurotrophic factor (called here factors) requires de novo formation of ‘survival complexes’ which are factor-stimula...

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Detalles Bibliográficos
Autores principales: Al Rahim, Md, Yoon, Yonejung, Dimovasili, Christina, Shao, Zhiping, Huang, Qian, Zhang, Emily, Kezunovic, Nebojsa, Chen, Lei, Schaffner, Adam, Huntley, George W, Ubarretxena-Belandia, Iban, Georgakopoulos, Anastasios, Robakis, Nikolaos K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520050/
https://www.ncbi.nlm.nih.gov/pubmed/33005890
http://dx.doi.org/10.1093/braincomms/fcaa100

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