Cargando…

APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease

Beta-amyloid deposition is a defining feature of Alzheimer’s disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human tissues is not fully understood. Using single-nucleus RNA sequencing of postmortem human brain with varied APOE and TRE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Aivi T., Wang, Kui, Hu, Gang, Wang, Xuran, Miao, Zhen, Azevedo, Joshua A., Suh, EunRan, Van Deerlin, Vivianna M., Choi, David, Roeder, Kathryn, Li, Mingyao, Lee, Edward B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520051/ https://www.ncbi.nlm.nih.gov/pubmed/32840654 http://dx.doi.org/10.1007/s00401-020-02200-3

Ejemplares similares

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
por: Zhao, Na, et al.
Publicado: (2022)

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease
por: Zhou, Yingyue, et al.
Publicado: (2018)

Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer’s Disease Mouse Model
por: Yuan, Qiuju, et al.
Publicado: (2021)

Reduced TREM2 activation in microglia of patients with Alzheimer's disease
por: Okuzono, Yuumi, et al.
Publicado: (2021)

TREM2 dependent and independent functions of microglia in Alzheimer’s disease
por: Hou, Jinchao, et al.
Publicado: (2022)

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives
por: Wolfe, Cody M., et al.
Publicado: (2018)

TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model
por: Wang, Yaming, et al.
Publicado: (2015)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer’s Disease
por: La Rosa, Francesca, et al.
Publicado: (2023)

The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer’s disease
por: von Saucken, Victoria E., et al.
Publicado: (2020)

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
por: Wang, Shoutang, et al.
Publicado: (2020)

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
por: Ewers, Michael, et al.
Publicado: (2020)

Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His
por: Robinson, John L., et al.
Publicado: (2015)

Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model
por: Li, Yujie, et al.
Publicado: (2020)

Genetic prediction of impulse control disorders in Parkinson's disease
por: Weintraub, Daniel, et al.
Publicado: (2022)

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia
por: Haney, Michael S., et al.
Publicado: (2023)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Molecular recognition of the interaction between ApoE and the TREM2 protein
por: Mai, Zhenhua, et al.
Publicado: (2022)

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
por: Fitz, Nicholas F., et al.
Publicado: (2020)

TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia
por: Winfree, Rebecca L., et al.
Publicado: (2023)

Microglia control small vessel calcification via TREM2
por: Zarb, Yvette, et al.
Publicado: (2021)

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo
por: Lee-Gosselin, Audrey, et al.
Publicado: (2023)

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
por: McQuade, Amanda, et al.
Publicado: (2020)

TREM2‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology
por: Fracassi, Anna, et al.
Publicado: (2022)

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
por: Rueda‐Carrasco, Javier, et al.
Publicado: (2023)

ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
por: Caesar, Ina, et al.
Publicado: (2023)

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
por: Qiao, Wenhui, et al.
Publicado: (2023)

Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer’s disease
por: Wang, Zhi-Bo, et al.
Publicado: (2022)

sTREM2 is associated with amyloid‐related p‐tau increases and glucose hypermetabolism in Alzheimer's disease
por: Biel, Davina, et al.
Publicado: (2023)

Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients
por: Eren, Neriman, et al.
Publicado: (2023)

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
por: Reifschneider, Anika, et al.
Publicado: (2022)

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin
por: Amlie-Wolf, Alexandre, et al.
Publicado: (2015)

sTREM2 mediates the associations of minimal depressive symptoms with amyloid pathology in prodromal Alzheimer’s disease: The CABLE study
por: Wang, Zhi-Bo, et al.
Publicado: (2022)

Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid‐soluble TREM2
por: Wang, Zuo‐Teng, et al.
Publicado: (2023)

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
por: Reich, Marvin, et al.
Publicado: (2021)

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias
por: Yin, Tao, et al.
Publicado: (2023)

Tau immunotherapy is associated with glial responses in FTLD-tau
por: Kim, Boram, et al.
Publicado: (2021)

TREM2 and microglia exosomes: a potential highway for pathological tau
por: Jain, Nimansha, et al.
Publicado: (2022)

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease
por: Fernandez, Celia G., et al.
Publicado: (2019)

Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
por: Giannini, Lucia A. A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_curd0ufdu0ssae3j25ooc2rbmj