Acute myeloid leukemia following a primary mediastinal germ cell tumor

INTRODUCTION: There is a known association between primary mediastinal germ cell tumor (PMGCT) and hematologic malignancy that is not linked to treatment. They are exceptionally rare entities with a low morbidity and a poor prognosis. CASE PRESENTATION: An 11‐year‐old boy presented with an anterior...

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Detalles Bibliográficos
Autores principales: Hong, Huimin, Su, Yan, Chen, Chenghao, He, Lejian, Zhu, Shuai, Lin, Wei, Jin, Mei, Wang, Xisi, Zhang, Ruidong, Zheng, Huyong, Zeng, Qi, Ma, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520107/
https://www.ncbi.nlm.nih.gov/pubmed/33150317
http://dx.doi.org/10.1002/ped4.12217
Descripción
Sumario:INTRODUCTION: There is a known association between primary mediastinal germ cell tumor (PMGCT) and hematologic malignancy that is not linked to treatment. They are exceptionally rare entities with a low morbidity and a poor prognosis. CASE PRESENTATION: An 11‐year‐old boy presented with an anterior mediastinal mass diagnosed as a malignant germ cell tumor on the basis of an excisional biopsy. He was found to have acute myeloid leukemia (AML) two years after the chemotherapy for his germ cell tumor. The clinical course was very aggressive with a survival time of only 1 week after diagnosis of AML associated with PMGCT. CONCLUSION: AML associated with PMGCT needs to be diagnosed correctly. Relevant examinations should be carried out in patients with PMGCTs during and after chemotherapy, and long‐term follow‐up is still necessary to reduce the risk of morbidity and mortality.

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