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Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China
IMPORTANCE: Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma. OBJECTIVE: To systematically summarize the clinical characteristics of children with neuroblastoma and e...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520112/ https://www.ncbi.nlm.nih.gov/pubmed/33150309 http://dx.doi.org/10.1002/ped4.12214 |
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author | Su, Yan Qin, Hong Chen, Chenghao Wang, Shengcai Zhang, Shihan Zhang, Dawei Jin, Mei Peng, Yun He, Lejian Wang, Xiaoman Qian, Suyun Qin, Maoquan Ge, Ming Zhang, Fuquan Zeng, Qi Wang, Huanmin Ma, Xiaoli Ni, Xin |
author_facet | Su, Yan Qin, Hong Chen, Chenghao Wang, Shengcai Zhang, Shihan Zhang, Dawei Jin, Mei Peng, Yun He, Lejian Wang, Xiaoman Qian, Suyun Qin, Maoquan Ge, Ming Zhang, Fuquan Zeng, Qi Wang, Huanmin Ma, Xiaoli Ni, Xin |
author_sort | Su, Yan |
collection | PubMed |
description | IMPORTANCE: Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma. OBJECTIVE: To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center. METHODS: This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed, treated, and followed‐up in the Hematology‐Oncology Center of Beijing Children’s Hospital from 2007 to 2019. RESULTS: The median age at diagnosis was 34 months; 80.8% of the patients were younger than 5 years of age. Notably, 243 patients (23.3%) were classified as low‐risk, 249 patients (23.9%) were classified as intermediate‐risk, and 549 (52.7%) were classified as high‐risk. Furthermore, 956 patients underwent surgical resections; 986 (94.7%) patients received chemotherapy; and 176 patients with high‐risk neuroblastoma received hematopoietic stem cell transplantation. The 5‐year event‐free survival (EFS) rate was 91.3% and 5‐year overall survival (OS) rate was 97.5% in low‐risk group; in the intermediate‐risk group, these rates were 85.1% and 96.7%, respectively, while they were 37.7% and 48.9% in the high‐risk group (P < 0.001 for both). The 5‐year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014 (P < 0.001). In total, 278 patients (26.7%) exhibited tumor relapse or progression; the median interval until relapse or progression was 14 months. Of the 233 patients who died, 83% died of relapse or progression of neuroblastoma and 4.3% died of therapy‐related complications. INTERPRETATION: The 5‐year OS rate was low in high‐risk patients, compared with low‐and intermediate‐risk patients. Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma. Additional treatment strategies should be sought to improve the prognosis of patients with high‐risk neuroblastoma. |
format | Online Article Text |
id | pubmed-7520112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75201122020-11-03 Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China Su, Yan Qin, Hong Chen, Chenghao Wang, Shengcai Zhang, Shihan Zhang, Dawei Jin, Mei Peng, Yun He, Lejian Wang, Xiaoman Qian, Suyun Qin, Maoquan Ge, Ming Zhang, Fuquan Zeng, Qi Wang, Huanmin Ma, Xiaoli Ni, Xin Pediatr Investig Original Article IMPORTANCE: Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma. OBJECTIVE: To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center. METHODS: This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed, treated, and followed‐up in the Hematology‐Oncology Center of Beijing Children’s Hospital from 2007 to 2019. RESULTS: The median age at diagnosis was 34 months; 80.8% of the patients were younger than 5 years of age. Notably, 243 patients (23.3%) were classified as low‐risk, 249 patients (23.9%) were classified as intermediate‐risk, and 549 (52.7%) were classified as high‐risk. Furthermore, 956 patients underwent surgical resections; 986 (94.7%) patients received chemotherapy; and 176 patients with high‐risk neuroblastoma received hematopoietic stem cell transplantation. The 5‐year event‐free survival (EFS) rate was 91.3% and 5‐year overall survival (OS) rate was 97.5% in low‐risk group; in the intermediate‐risk group, these rates were 85.1% and 96.7%, respectively, while they were 37.7% and 48.9% in the high‐risk group (P < 0.001 for both). The 5‐year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014 (P < 0.001). In total, 278 patients (26.7%) exhibited tumor relapse or progression; the median interval until relapse or progression was 14 months. Of the 233 patients who died, 83% died of relapse or progression of neuroblastoma and 4.3% died of therapy‐related complications. INTERPRETATION: The 5‐year OS rate was low in high‐risk patients, compared with low‐and intermediate‐risk patients. Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma. Additional treatment strategies should be sought to improve the prognosis of patients with high‐risk neuroblastoma. John Wiley and Sons Inc. 2020-09-27 /pmc/articles/PMC7520112/ /pubmed/33150309 http://dx.doi.org/10.1002/ped4.12214 Text en © 2020 The Authors. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Article Su, Yan Qin, Hong Chen, Chenghao Wang, Shengcai Zhang, Shihan Zhang, Dawei Jin, Mei Peng, Yun He, Lejian Wang, Xiaoman Qian, Suyun Qin, Maoquan Ge, Ming Zhang, Fuquan Zeng, Qi Wang, Huanmin Ma, Xiaoli Ni, Xin Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_full | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_fullStr | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_full_unstemmed | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_short | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_sort | treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520112/ https://www.ncbi.nlm.nih.gov/pubmed/33150309 http://dx.doi.org/10.1002/ped4.12214 |
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