Molecular and behavioural abnormalities in the FUS‐tg mice mimic frontotemporal lobar degeneration: Effects of old and new anti‐inflammatory therapies

Genetic mutations in FUS, a DNA/RNA‐binding protein, are associated with inherited forms of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). A novel transgenic FUS[1‐359]‐tg mouse line recapitulates core hallmarks of human ALS in the spinal cord, including neuroinfla...

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Detalles Bibliográficos
Autores principales: de Munter, Johannes, Babaevskaya, Diana, Wolters, Erik Ch., Pavlov, Dmitrii, Lysikova, Ekaterina, V. Kalueff, Allan, Gorlova, Anna, Oplatchikova, Margarita, Pomytkin, Igor A., Proshin, Andrey, Umriukhin, Aleksei, Lesch, Klaus‐Peter, Strekalova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520339/
https://www.ncbi.nlm.nih.gov/pubmed/32667139
http://dx.doi.org/10.1111/jcmm.15628

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