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Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil

OBJECTIVE: Compared with Occident's data, the incidence of Human papillomavirus (HPV)‐driven oropharyngeal squamous cell carcinomas (OPSCCs) had been reported as relatively low in Mainland China. The objective of this study was to report the integrated prevalence of HPV and Epstein‐Barr virus (...

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Autores principales: Xu, Tingting, Shen, Chunying, Wei, Ye, Hu, Chaosu, Wang, Yu, Xiang, Jun, Sun, Guo‐Hua, Su, Fengtao, Wang, Qifeng, Lu, Xueguan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520352/
https://www.ncbi.nlm.nih.gov/pubmed/32717137
http://dx.doi.org/10.1002/cam4.3339
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author Xu, Tingting
Shen, Chunying
Wei, Ye
Hu, Chaosu
Wang, Yu
Xiang, Jun
Sun, Guo‐Hua
Su, Fengtao
Wang, Qifeng
Lu, Xueguan
author_facet Xu, Tingting
Shen, Chunying
Wei, Ye
Hu, Chaosu
Wang, Yu
Xiang, Jun
Sun, Guo‐Hua
Su, Fengtao
Wang, Qifeng
Lu, Xueguan
author_sort Xu, Tingting
collection PubMed
description OBJECTIVE: Compared with Occident's data, the incidence of Human papillomavirus (HPV)‐driven oropharyngeal squamous cell carcinomas (OPSCCs) had been reported as relatively low in Mainland China. The objective of this study was to report the integrated prevalence of HPV and Epstein‐Barr virus (EBV), and further evaluate the different behaviors of HPV‐positive and ‐negative OPSCCs in eastern China. METHODS: In a cohort of 170 nonmetastatic OPSCCs treated from January 2007 to July 2019, p16 protein expression, HPV genotypes, and Epstein‐Barr virus‐encoded RNA (EBER) were determined by immunohistochemistry (IHC) and in situ hybridization (ISH). The clinical and pathologic findings were further collected and analyzed to comprehensively reveal the behaviors of Chinese OPSCCs. RESULTS: Out of the 170 tumor tissues evaluated, 57.6% (98) samples had positive p16 expressions. A total of 65.1% (99/152) samples had positive HPV genotypes, besides HPV16 (92/152), HPV11, 18, 33, 53, and 58 were also detected. The positive rate of EBER was 7.2% (9/124), and the co‐infection rate of EBV/HPV was 4.0%. Related to the unequal distributions of p16 expression, HPV‐related tumors arisen from tonsillar and non‐tonsillar accounted for 68.8% (75/109) and 37.7% (23/61) of their cases, respectively (P < .001). With a median follow‐up time of 13.1 months, significant survival advantages of HPV‐related OSPCC were observed; 1‐year OS, PFS, RFS, and MFS were 83.2% vs 96.7% (P < .001), 71.6% vs 96.2% (P < .001), 77.7% vs 96.2% (P = .002), and 90.4% vs 100.0% (P = .024) in p16‐negative and ‐positive cases, respectively. CONCLUSIONS: The relative percent of HPV‐positive OPSCCs in this study is close to the positive rate in many Western countries and a strong predilection was discovered for the tonsillar. The EBV infection and co‐infection of HPV/EBV were largely low. The prognosis of HPV‐positive OSPCCs was more favorable than its negative counterpart.
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spelling pubmed-75203522020-09-30 Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil Xu, Tingting Shen, Chunying Wei, Ye Hu, Chaosu Wang, Yu Xiang, Jun Sun, Guo‐Hua Su, Fengtao Wang, Qifeng Lu, Xueguan Cancer Med Clinical Cancer Research OBJECTIVE: Compared with Occident's data, the incidence of Human papillomavirus (HPV)‐driven oropharyngeal squamous cell carcinomas (OPSCCs) had been reported as relatively low in Mainland China. The objective of this study was to report the integrated prevalence of HPV and Epstein‐Barr virus (EBV), and further evaluate the different behaviors of HPV‐positive and ‐negative OPSCCs in eastern China. METHODS: In a cohort of 170 nonmetastatic OPSCCs treated from January 2007 to July 2019, p16 protein expression, HPV genotypes, and Epstein‐Barr virus‐encoded RNA (EBER) were determined by immunohistochemistry (IHC) and in situ hybridization (ISH). The clinical and pathologic findings were further collected and analyzed to comprehensively reveal the behaviors of Chinese OPSCCs. RESULTS: Out of the 170 tumor tissues evaluated, 57.6% (98) samples had positive p16 expressions. A total of 65.1% (99/152) samples had positive HPV genotypes, besides HPV16 (92/152), HPV11, 18, 33, 53, and 58 were also detected. The positive rate of EBER was 7.2% (9/124), and the co‐infection rate of EBV/HPV was 4.0%. Related to the unequal distributions of p16 expression, HPV‐related tumors arisen from tonsillar and non‐tonsillar accounted for 68.8% (75/109) and 37.7% (23/61) of their cases, respectively (P < .001). With a median follow‐up time of 13.1 months, significant survival advantages of HPV‐related OSPCC were observed; 1‐year OS, PFS, RFS, and MFS were 83.2% vs 96.7% (P < .001), 71.6% vs 96.2% (P < .001), 77.7% vs 96.2% (P = .002), and 90.4% vs 100.0% (P = .024) in p16‐negative and ‐positive cases, respectively. CONCLUSIONS: The relative percent of HPV‐positive OPSCCs in this study is close to the positive rate in many Western countries and a strong predilection was discovered for the tonsillar. The EBV infection and co‐infection of HPV/EBV were largely low. The prognosis of HPV‐positive OSPCCs was more favorable than its negative counterpart. John Wiley and Sons Inc. 2020-07-27 /pmc/articles/PMC7520352/ /pubmed/32717137 http://dx.doi.org/10.1002/cam4.3339 Text en © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Xu, Tingting
Shen, Chunying
Wei, Ye
Hu, Chaosu
Wang, Yu
Xiang, Jun
Sun, Guo‐Hua
Su, Fengtao
Wang, Qifeng
Lu, Xueguan
Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil
title Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil
title_full Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil
title_fullStr Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil
title_full_unstemmed Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil
title_short Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil
title_sort human papillomavirus (hpv) in chinese oropharyngeal squamous cell carcinoma (opscc): a strong predilection for the tonsil
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520352/
https://www.ncbi.nlm.nih.gov/pubmed/32717137
http://dx.doi.org/10.1002/cam4.3339
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