Cargando…

Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective

The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize a clinically relevant food effect. Here, the predictive per...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riedmaier, Arian Emami, DeMent, Kevin, Huckle, James, Bransford, Phil, Stillhart, Cordula, Lloyd, Richard, Alluri, Ravindra, Basu, Sumit, Chen, Yuan, Dhamankar, Varsha, Dodd, Stephanie, Kulkarni, Priyanka, Olivares-Morales, Andrés, Peng, Chi-Chi, Pepin, Xavier, Ren, Xiaojun, Tran, Thuy, Tistaert, Christophe, Heimbach, Tycho, Kesisoglou, Filippos, Wagner, Christian, Parrott, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520419/ https://www.ncbi.nlm.nih.gov/pubmed/32981010 http://dx.doi.org/10.1208/s12248-020-00508-2

Ejemplares similares

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter‐Mediated Clearances
por: Emami Riedmaier, Ariane, et al.
Publicado: (2016)

Physiologically Based Biopharmaceutics Modeling of Food Effect for Basmisanil: A Retrospective Case Study of the Utility for Formulation Bridging
por: Belubbi, Tejashree, et al.
Publicado: (2023)

Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery
por: Naga, Doha, et al.
Publicado: (2022)

Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
por: Van der Veken, Matthias, et al.
Publicado: (2022)

Correction: Van der Veken et al. Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study. Pharmaceutics 2022, 14, 1935
por: Van der Veken, Matthias, et al.
Publicado: (2023)

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
por: Kuepfer, L, et al.
Publicado: (2016)

Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report
por: Al Shoyaib, Abdullah, et al.
Publicado: (2023)

Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding
por: Van der Veken, Matthias, et al.
Publicado: (2023)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK
por: Wagner, C, et al.
Publicado: (2015)

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis
por: Burt, Howard J., et al.
Publicado: (2016)

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates
por: Reddy, Micaela B., et al.
Publicado: (2021)

PBPK modeling and simulation in drug research and development
por: Zhuang, Xiaomei, et al.
Publicado: (2016)

Spatial Epidemiology of Salmonellosis in Florida, 2009–2018
por: Li, Xiaolong, et al.
Publicado: (2021)

Molecular Epidemiology of Salmonellosis in Florida, USA, 2017–2018
por: Singh, Nitya, et al.
Publicado: (2021)

A Workflow for Global Sensitivity Analysis of PBPK Models
por: McNally, Kevin, et al.
Publicado: (2011)

PBPK Modeling on Organs-on-Chips: An Overview of Recent Advancements
por: Yang, Yi, et al.
Publicado: (2022)

Permeability of Gemcitabine and PBPK Modeling to Assess Oral Administration
por: Ferreira, Abigail, et al.
Publicado: (2021)

Schiedeahaakoaensis, a new facultatively autogamous species of Schiedea sect. Mononeura (Caryophyllaceae) from the Hawaiian Islands
por: Wagner, Warren L., et al.
Publicado: (2022)

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human
por: Campbell, Jerry L., et al.
Publicado: (2016)

Where Do PBPK Models Stand in Pharmacometrics and Systems Pharmacology?
por: Jamei, Masoud
Publicado: (2020)

Current PBPK Models: Are They Predicting Tissue Drug Concentration Correctly?
por: Ibarra, Manuel, et al.
Publicado: (2020)

PBPK model reporting template for chemical risk assessment applications
por: Tan, Yu-Mei, et al.
Publicado: (2020)

PBPK Modelling of Dexamethasone in Patients With COVID-19 and Liver Disease
por: Montanha, Maiara Camotti, et al.
Publicado: (2022)

PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes
por: Levitt, David G.
Publicado: (2018)

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components
por: Sterner, Teresa R., et al.
Publicado: (2023)

Population pharmacokinetic analysis of RO5459072, a low water‐soluble drug exhibiting complex food–drug interactions
por: Kratochwil, Nicole A., et al.
Publicado: (2021)

Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?
por: Frechen, Sebastian, et al.
Publicado: (2022)

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives
por: McAllister, Mark, et al.
Publicado: (2019)

A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models
por: Yau, Estelle, et al.
Publicado: (2023)

Statistical analysis of Fisher et al. PBPK model of trichloroethylene kinetics.
por: Bois, F Y
Publicado: (2000)

Statistical analysis of Clewell et al. PBPK model of trichloroethylene kinetics.
por: Bois, F Y
Publicado: (2000)

Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats
por: Cuello, W. S., et al.
Publicado: (2012)

PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water
por: Breckenridge, Charles B., et al.
Publicado: (2016)

Analysis of biomarker utility using a PBPK/PD model for carbaryl
por: Phillips, Martin B., et al.
Publicado: (2014)

Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials
por: Utembe, Wells, et al.
Publicado: (2020)

Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development
por: Shaik, Abdul Naveed, et al.
Publicado: (2019)

Editorial: Exploring Maternal-Fetal Pharmacology Through PBPK Modeling Approaches
por: Dallmann, André, et al.
Publicado: (2022)

PBPK perspective on alternative CYP3A4 inducers for rifampin
por: Chen, Kuan‐Fu, et al.
Publicado: (2022)

Bioequivalence study of ipratropium bromide inhalation aerosol using PBPK modelling
por: Zhang, Jisheng, et al.
Publicado: (2023)

Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
por: Denninger, Alexander, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rbme938otqt53b3fs52gst86a6