Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1

A modeling and simulation approach was used for quantitative comparison of a new generation HER2 antibody drug conjugate (ADC, PF-06804103) with trastuzumab-DM1 (T-DM1). To compare preclinical efficacy, the pharmacokinetic (PK)/pharmacodynamic (PD) relationship of PF-06804103 and T-DM1 was determine...

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Detalles Bibliográficos
Autores principales: Betts, Alison, Clark, Tracey, Jasper, Paul, Tolsma, John, van der Graaf, Piet H., Graziani, Edmund I., Rosfjord, Edward, Sung, Matthew, Ma, Dangshe, Barletta, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520420/
https://www.ncbi.nlm.nih.gov/pubmed/32710210
http://dx.doi.org/10.1007/s10928-020-09702-3

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