Epigenetic basis of Alzheimer disease

Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this re...

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Autores principales: Tecalco-Cruz, Angeles C, Ramírez-Jarquín, Josué O, Alvarez-Sánchez, María E, Zepeda-Cervantes, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520642/
https://www.ncbi.nlm.nih.gov/pubmed/33024518
http://dx.doi.org/10.4331/wjbc.v11.i2.62
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author Tecalco-Cruz, Angeles C
Ramírez-Jarquín, Josué O
Alvarez-Sánchez, María E
Zepeda-Cervantes, Jesus
author_facet Tecalco-Cruz, Angeles C
Ramírez-Jarquín, Josué O
Alvarez-Sánchez, María E
Zepeda-Cervantes, Jesus
author_sort Tecalco-Cruz, Angeles C
collection PubMed
description Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this review, we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD. The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.
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spelling pubmed-75206422020-10-05 Epigenetic basis of Alzheimer disease Tecalco-Cruz, Angeles C Ramírez-Jarquín, Josué O Alvarez-Sánchez, María E Zepeda-Cervantes, Jesus World J Biol Chem Minireviews Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this review, we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD. The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD. Baishideng Publishing Group Inc 2020-09-27 2020-09-27 /pmc/articles/PMC7520642/ /pubmed/33024518 http://dx.doi.org/10.4331/wjbc.v11.i2.62 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Tecalco-Cruz, Angeles C
Ramírez-Jarquín, Josué O
Alvarez-Sánchez, María E
Zepeda-Cervantes, Jesus
Epigenetic basis of Alzheimer disease
title Epigenetic basis of Alzheimer disease
title_full Epigenetic basis of Alzheimer disease
title_fullStr Epigenetic basis of Alzheimer disease
title_full_unstemmed Epigenetic basis of Alzheimer disease
title_short Epigenetic basis of Alzheimer disease
title_sort epigenetic basis of alzheimer disease
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520642/
https://www.ncbi.nlm.nih.gov/pubmed/33024518
http://dx.doi.org/10.4331/wjbc.v11.i2.62
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