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Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE

Asthma is one of the most common respiratory diseases encountered in clinical practice. Although the vast majority of asthmatics can be adequately controlled with inhaled steroids and other preventer medications, a small proportion remain uncontrolled. Anti-IgE treatment with omalizumab has been pro...

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Detalles Bibliográficos
Autores principales: R, Divya, Venkitakrishnan, Rajesh, Augustine, Jolsana, Cleetus, Melcy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520673/
https://www.ncbi.nlm.nih.gov/pubmed/33014501
http://dx.doi.org/10.1155/2020/8898454
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author R, Divya
Venkitakrishnan, Rajesh
Augustine, Jolsana
Cleetus, Melcy
author_facet R, Divya
Venkitakrishnan, Rajesh
Augustine, Jolsana
Cleetus, Melcy
author_sort R, Divya
collection PubMed
description Asthma is one of the most common respiratory diseases encountered in clinical practice. Although the vast majority of asthmatics can be adequately controlled with inhaled steroids and other preventer medications, a small proportion remain uncontrolled. Anti-IgE treatment with omalizumab has been proposed in patients as a preferred approach in step 5 asthma therapy according to GINA guidelines. Although therapy with this molecule is approved for patients with atopic asthma and pretreatment serum IgE levels of 30-1500 only, there have been a few reports of its efficacy in subjects outside this reference IgE range. We report the case of a middle-aged lady with severe corticosteroid-dependent asthma and low serum IgE levels who was successfully treated with 9 months of omalizumab therapy. She gained good asthma control and was tapered off steroid use by the fifth month of therapy with omalizumab. The case report stresses the need for further investigation into expanding the spectrum of omalizumab usage in asthma beyond the current IgE suitability range.
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spelling pubmed-75206732020-10-02 Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE R, Divya Venkitakrishnan, Rajesh Augustine, Jolsana Cleetus, Melcy Case Rep Pulmonol Case Report Asthma is one of the most common respiratory diseases encountered in clinical practice. Although the vast majority of asthmatics can be adequately controlled with inhaled steroids and other preventer medications, a small proportion remain uncontrolled. Anti-IgE treatment with omalizumab has been proposed in patients as a preferred approach in step 5 asthma therapy according to GINA guidelines. Although therapy with this molecule is approved for patients with atopic asthma and pretreatment serum IgE levels of 30-1500 only, there have been a few reports of its efficacy in subjects outside this reference IgE range. We report the case of a middle-aged lady with severe corticosteroid-dependent asthma and low serum IgE levels who was successfully treated with 9 months of omalizumab therapy. She gained good asthma control and was tapered off steroid use by the fifth month of therapy with omalizumab. The case report stresses the need for further investigation into expanding the spectrum of omalizumab usage in asthma beyond the current IgE suitability range. Hindawi 2020-09-14 /pmc/articles/PMC7520673/ /pubmed/33014501 http://dx.doi.org/10.1155/2020/8898454 Text en Copyright © 2020 Divya R et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
R, Divya
Venkitakrishnan, Rajesh
Augustine, Jolsana
Cleetus, Melcy
Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE
title Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE
title_full Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE
title_fullStr Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE
title_full_unstemmed Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE
title_short Efficacy of Omalizumab Therapy in an Asthmatic with Low IgE
title_sort efficacy of omalizumab therapy in an asthmatic with low ige
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520673/
https://www.ncbi.nlm.nih.gov/pubmed/33014501
http://dx.doi.org/10.1155/2020/8898454
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