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Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520686/ https://www.ncbi.nlm.nih.gov/pubmed/33014190 http://dx.doi.org/10.1155/2020/9292560 |
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author | Petruzzelli, Maria G. Marzulli, Lucia Margari, Francesco De Giacomo, Andrea Gabellone, Alessandra Giannico, Orazio V. Margari, Lucia |
author_facet | Petruzzelli, Maria G. Marzulli, Lucia Margari, Francesco De Giacomo, Andrea Gabellone, Alessandra Giannico, Orazio V. Margari, Lucia |
author_sort | Petruzzelli, Maria G. |
collection | PubMed |
description | Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children with ASD (ASD group, n = 54) compared to children affected by other neurological and psychiatric disorders (non-ASD group, n = 36). All patients were admitted at the Complex Operative Unit of Child Neuropsychiatry, Polyclinic of Bari, Italy. 25(OH)D was quantified by chemiluminescence immunoassay and level defined as: deficiency (<20 ng/mL); insufficiency (20–30); normality (30-100); toxicity (>100). Statistical analysis was performed using SPSS20 (significance < 0.05). The ASD group showed 25(OH)D a mean level significantly lower than control (p = 0.014). Multivariable logistic regression analysis showed an association between ASD and vitamin D deficiency (p = 0.006). The nature of such association is unclear. Vitamin D deficiency may probably act as a risk factor for the development of ASD. Further studies are needed to unravel the role of vitamin D in ASD etiology and investigate its therapeutic potential. |
format | Online Article Text |
id | pubmed-7520686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75206862020-10-02 Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study Petruzzelli, Maria G. Marzulli, Lucia Margari, Francesco De Giacomo, Andrea Gabellone, Alessandra Giannico, Orazio V. Margari, Lucia Dis Markers Research Article Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children with ASD (ASD group, n = 54) compared to children affected by other neurological and psychiatric disorders (non-ASD group, n = 36). All patients were admitted at the Complex Operative Unit of Child Neuropsychiatry, Polyclinic of Bari, Italy. 25(OH)D was quantified by chemiluminescence immunoassay and level defined as: deficiency (<20 ng/mL); insufficiency (20–30); normality (30-100); toxicity (>100). Statistical analysis was performed using SPSS20 (significance < 0.05). The ASD group showed 25(OH)D a mean level significantly lower than control (p = 0.014). Multivariable logistic regression analysis showed an association between ASD and vitamin D deficiency (p = 0.006). The nature of such association is unclear. Vitamin D deficiency may probably act as a risk factor for the development of ASD. Further studies are needed to unravel the role of vitamin D in ASD etiology and investigate its therapeutic potential. Hindawi 2020-09-18 /pmc/articles/PMC7520686/ /pubmed/33014190 http://dx.doi.org/10.1155/2020/9292560 Text en Copyright © 2020 Maria G. Petruzzelli et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Petruzzelli, Maria G. Marzulli, Lucia Margari, Francesco De Giacomo, Andrea Gabellone, Alessandra Giannico, Orazio V. Margari, Lucia Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study |
title | Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study |
title_full | Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study |
title_fullStr | Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study |
title_full_unstemmed | Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study |
title_short | Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study |
title_sort | vitamin d deficiency in autism spectrum disorder: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520686/ https://www.ncbi.nlm.nih.gov/pubmed/33014190 http://dx.doi.org/10.1155/2020/9292560 |
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