Cargando…

Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study

Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concen...

Descripción completa

Detalles Bibliográficos
Autores principales: Petruzzelli, Maria G., Marzulli, Lucia, Margari, Francesco, De Giacomo, Andrea, Gabellone, Alessandra, Giannico, Orazio V., Margari, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520686/
https://www.ncbi.nlm.nih.gov/pubmed/33014190
http://dx.doi.org/10.1155/2020/9292560
_version_ 1783587826224332800
author Petruzzelli, Maria G.
Marzulli, Lucia
Margari, Francesco
De Giacomo, Andrea
Gabellone, Alessandra
Giannico, Orazio V.
Margari, Lucia
author_facet Petruzzelli, Maria G.
Marzulli, Lucia
Margari, Francesco
De Giacomo, Andrea
Gabellone, Alessandra
Giannico, Orazio V.
Margari, Lucia
author_sort Petruzzelli, Maria G.
collection PubMed
description Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children with ASD (ASD group, n = 54) compared to children affected by other neurological and psychiatric disorders (non-ASD group, n = 36). All patients were admitted at the Complex Operative Unit of Child Neuropsychiatry, Polyclinic of Bari, Italy. 25(OH)D was quantified by chemiluminescence immunoassay and level defined as: deficiency (<20 ng/mL); insufficiency (20–30); normality (30-100); toxicity (>100). Statistical analysis was performed using SPSS20 (significance < 0.05). The ASD group showed 25(OH)D a mean level significantly lower than control (p = 0.014). Multivariable logistic regression analysis showed an association between ASD and vitamin D deficiency (p = 0.006). The nature of such association is unclear. Vitamin D deficiency may probably act as a risk factor for the development of ASD. Further studies are needed to unravel the role of vitamin D in ASD etiology and investigate its therapeutic potential.
format Online
Article
Text
id pubmed-7520686
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-75206862020-10-02 Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study Petruzzelli, Maria G. Marzulli, Lucia Margari, Francesco De Giacomo, Andrea Gabellone, Alessandra Giannico, Orazio V. Margari, Lucia Dis Markers Research Article Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children with ASD (ASD group, n = 54) compared to children affected by other neurological and psychiatric disorders (non-ASD group, n = 36). All patients were admitted at the Complex Operative Unit of Child Neuropsychiatry, Polyclinic of Bari, Italy. 25(OH)D was quantified by chemiluminescence immunoassay and level defined as: deficiency (<20 ng/mL); insufficiency (20–30); normality (30-100); toxicity (>100). Statistical analysis was performed using SPSS20 (significance < 0.05). The ASD group showed 25(OH)D a mean level significantly lower than control (p = 0.014). Multivariable logistic regression analysis showed an association between ASD and vitamin D deficiency (p = 0.006). The nature of such association is unclear. Vitamin D deficiency may probably act as a risk factor for the development of ASD. Further studies are needed to unravel the role of vitamin D in ASD etiology and investigate its therapeutic potential. Hindawi 2020-09-18 /pmc/articles/PMC7520686/ /pubmed/33014190 http://dx.doi.org/10.1155/2020/9292560 Text en Copyright © 2020 Maria G. Petruzzelli et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Petruzzelli, Maria G.
Marzulli, Lucia
Margari, Francesco
De Giacomo, Andrea
Gabellone, Alessandra
Giannico, Orazio V.
Margari, Lucia
Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
title Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
title_full Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
title_fullStr Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
title_full_unstemmed Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
title_short Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study
title_sort vitamin d deficiency in autism spectrum disorder: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520686/
https://www.ncbi.nlm.nih.gov/pubmed/33014190
http://dx.doi.org/10.1155/2020/9292560
work_keys_str_mv AT petruzzellimariag vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy
AT marzullilucia vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy
AT margarifrancesco vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy
AT degiacomoandrea vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy
AT gabellonealessandra vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy
AT giannicooraziov vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy
AT margarilucia vitaminddeficiencyinautismspectrumdisorderacrosssectionalstudy