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Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis

BACKGROUND: Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed to examine the relationship between the ACPA repertoire and lung abnormalities on high-resolution CT (HRCT) in patients with earlyuntreate...

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Autores principales: Joshua, Vijay, Hensvold, Aase Haj, Reynisdottir, Gudrun, Hansson, Monica, Cornillet, Martin, Nogueira, Leonor, Serre, Guy, Nyren, Sven, Karimi, Reza, Eklund, Anders, Sköld, Magnus, Grunewald, Johan, Chatzidionysiou, Katerina, Catrina, Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520701/
https://www.ncbi.nlm.nih.gov/pubmed/32917833
http://dx.doi.org/10.1136/rmdopen-2020-001278
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author Joshua, Vijay
Hensvold, Aase Haj
Reynisdottir, Gudrun
Hansson, Monica
Cornillet, Martin
Nogueira, Leonor
Serre, Guy
Nyren, Sven
Karimi, Reza
Eklund, Anders
Sköld, Magnus
Grunewald, Johan
Chatzidionysiou, Katerina
Catrina, Anca
author_facet Joshua, Vijay
Hensvold, Aase Haj
Reynisdottir, Gudrun
Hansson, Monica
Cornillet, Martin
Nogueira, Leonor
Serre, Guy
Nyren, Sven
Karimi, Reza
Eklund, Anders
Sköld, Magnus
Grunewald, Johan
Chatzidionysiou, Katerina
Catrina, Anca
author_sort Joshua, Vijay
collection PubMed
description BACKGROUND: Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed to examine the relationship between the ACPA repertoire and lung abnormalities on high-resolution CT (HRCT) in patients with earlyuntreated RA. METHODS: 106 patients with newly diagnosed untreated RA were examined with HRCT of the lungs. Blood samples were analysed for presence of rheumatoid factor (RF) and ACPA using either a CCP2 detection kit or an immunochip containing 10 different citrullinated peptides. Association between HRCT findings and the antibody repertoire was assessed by logistic regression analysis. RESULTS: The number (%) of patients with HRCT abnormalities was 58 (54.7%) for parenchymal abnormalities and 68 (64.2%) for airway abnormalities. CCP2 IgG, RF IgA and antibodies against citrullinated fibrinogen were associated with the presence of parenchymal lung abnormalities. Interestingly, a high number of ACPA fine specificities gave a high risk of having parenchymal lung abnormalities at the time of RA diagnosis. No significant signals were identified between ACPA specificities and risk for airway abnormalities. CONCLUSIONS: The presence of RF and ACPAs (especially against citrullinated fibrinogen peptides) as well as high number of ACPAs fine specificities are associated with parenchymal lung abnormalities in patients with early, untreated RA. This provides further support for an important pathogenic link between the lung and systemic autoimmunity, contributing to RA development.
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spelling pubmed-75207012020-10-14 Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis Joshua, Vijay Hensvold, Aase Haj Reynisdottir, Gudrun Hansson, Monica Cornillet, Martin Nogueira, Leonor Serre, Guy Nyren, Sven Karimi, Reza Eklund, Anders Sköld, Magnus Grunewald, Johan Chatzidionysiou, Katerina Catrina, Anca RMD Open Rheumatoid Arthritis BACKGROUND: Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed to examine the relationship between the ACPA repertoire and lung abnormalities on high-resolution CT (HRCT) in patients with earlyuntreated RA. METHODS: 106 patients with newly diagnosed untreated RA were examined with HRCT of the lungs. Blood samples were analysed for presence of rheumatoid factor (RF) and ACPA using either a CCP2 detection kit or an immunochip containing 10 different citrullinated peptides. Association between HRCT findings and the antibody repertoire was assessed by logistic regression analysis. RESULTS: The number (%) of patients with HRCT abnormalities was 58 (54.7%) for parenchymal abnormalities and 68 (64.2%) for airway abnormalities. CCP2 IgG, RF IgA and antibodies against citrullinated fibrinogen were associated with the presence of parenchymal lung abnormalities. Interestingly, a high number of ACPA fine specificities gave a high risk of having parenchymal lung abnormalities at the time of RA diagnosis. No significant signals were identified between ACPA specificities and risk for airway abnormalities. CONCLUSIONS: The presence of RF and ACPAs (especially against citrullinated fibrinogen peptides) as well as high number of ACPAs fine specificities are associated with parenchymal lung abnormalities in patients with early, untreated RA. This provides further support for an important pathogenic link between the lung and systemic autoimmunity, contributing to RA development. BMJ Publishing Group 2020-09-10 /pmc/articles/PMC7520701/ /pubmed/32917833 http://dx.doi.org/10.1136/rmdopen-2020-001278 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Rheumatoid Arthritis
Joshua, Vijay
Hensvold, Aase Haj
Reynisdottir, Gudrun
Hansson, Monica
Cornillet, Martin
Nogueira, Leonor
Serre, Guy
Nyren, Sven
Karimi, Reza
Eklund, Anders
Sköld, Magnus
Grunewald, Johan
Chatzidionysiou, Katerina
Catrina, Anca
Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
title Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
title_full Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
title_fullStr Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
title_full_unstemmed Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
title_short Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
title_sort association between number and type of different acpa fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
topic Rheumatoid Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520701/
https://www.ncbi.nlm.nih.gov/pubmed/32917833
http://dx.doi.org/10.1136/rmdopen-2020-001278
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