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Pre- and intraoperative predictors of acute kidney injury after liver transplantation

BACKGROUND: Acute kidney injury (AKI) after liver transplantation (LT) is a frequent and multifactorial event related to increased morbidity and mortality. Risk factors for AKI after LT still need to be clarified. AIM: To identify the predictors of acute kidney injury after liver transplantation. ME...

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Autores principales: Mrzljak, Anna, Franusic, Lucija, Pavicic-Saric, Jadranka, Kelava, Tomislav, Jurekovic, Zeljka, Kocman, Branislav, Mikulic, Danko, Budimir-Bekan, Ivan, Knotek, Mladen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520778/
https://www.ncbi.nlm.nih.gov/pubmed/33024760
http://dx.doi.org/10.12998/wjcc.v8.i18.4034
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author Mrzljak, Anna
Franusic, Lucija
Pavicic-Saric, Jadranka
Kelava, Tomislav
Jurekovic, Zeljka
Kocman, Branislav
Mikulic, Danko
Budimir-Bekan, Ivan
Knotek, Mladen
author_facet Mrzljak, Anna
Franusic, Lucija
Pavicic-Saric, Jadranka
Kelava, Tomislav
Jurekovic, Zeljka
Kocman, Branislav
Mikulic, Danko
Budimir-Bekan, Ivan
Knotek, Mladen
author_sort Mrzljak, Anna
collection PubMed
description BACKGROUND: Acute kidney injury (AKI) after liver transplantation (LT) is a frequent and multifactorial event related to increased morbidity and mortality. Risk factors for AKI after LT still need to be clarified. AIM: To identify the predictors of acute kidney injury after liver transplantation. METHODS: The frequency and pre- and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia. AKI was defined according to the Kidney Disease: Improving Global Outcomes criteria. RESULTS: Out of 205 patients (mean age 57 ± 10 years; 73.7% males, 52.7% with alcohol-related liver disease) 93 (45.36%) developed AKI, and the majority of them (58.06%) had stage 1. Only 5.38% of patients required renal replacement therapy after LT. The majority of patients (82.8%) developed AKI within the first two days after the procedure. Multivariate logistic regression identified pre-LT body mass index (OR = 1.1, 95%CI: 1.05-1.24) and red blood cell transfusion (OR = 1.66, 95%CI: 1.09-2.53) as independent predictors of early post-LT AKI occurrence. 30-d survival after LT was significantly better for patients without AKI (P = 0.01). CONCLUSION: Early AKI after LT is a frequent event that negatively impacts short-term survival. The pathogenesis of AKI is multifactorial, but pre-LT BMI and intraoperative volume shifts are major contributors.
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spelling pubmed-75207782020-10-05 Pre- and intraoperative predictors of acute kidney injury after liver transplantation Mrzljak, Anna Franusic, Lucija Pavicic-Saric, Jadranka Kelava, Tomislav Jurekovic, Zeljka Kocman, Branislav Mikulic, Danko Budimir-Bekan, Ivan Knotek, Mladen World J Clin Cases Retrospective Study BACKGROUND: Acute kidney injury (AKI) after liver transplantation (LT) is a frequent and multifactorial event related to increased morbidity and mortality. Risk factors for AKI after LT still need to be clarified. AIM: To identify the predictors of acute kidney injury after liver transplantation. METHODS: The frequency and pre- and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia. AKI was defined according to the Kidney Disease: Improving Global Outcomes criteria. RESULTS: Out of 205 patients (mean age 57 ± 10 years; 73.7% males, 52.7% with alcohol-related liver disease) 93 (45.36%) developed AKI, and the majority of them (58.06%) had stage 1. Only 5.38% of patients required renal replacement therapy after LT. The majority of patients (82.8%) developed AKI within the first two days after the procedure. Multivariate logistic regression identified pre-LT body mass index (OR = 1.1, 95%CI: 1.05-1.24) and red blood cell transfusion (OR = 1.66, 95%CI: 1.09-2.53) as independent predictors of early post-LT AKI occurrence. 30-d survival after LT was significantly better for patients without AKI (P = 0.01). CONCLUSION: Early AKI after LT is a frequent event that negatively impacts short-term survival. The pathogenesis of AKI is multifactorial, but pre-LT BMI and intraoperative volume shifts are major contributors. Baishideng Publishing Group Inc 2020-09-26 2020-09-26 /pmc/articles/PMC7520778/ /pubmed/33024760 http://dx.doi.org/10.12998/wjcc.v8.i18.4034 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Mrzljak, Anna
Franusic, Lucija
Pavicic-Saric, Jadranka
Kelava, Tomislav
Jurekovic, Zeljka
Kocman, Branislav
Mikulic, Danko
Budimir-Bekan, Ivan
Knotek, Mladen
Pre- and intraoperative predictors of acute kidney injury after liver transplantation
title Pre- and intraoperative predictors of acute kidney injury after liver transplantation
title_full Pre- and intraoperative predictors of acute kidney injury after liver transplantation
title_fullStr Pre- and intraoperative predictors of acute kidney injury after liver transplantation
title_full_unstemmed Pre- and intraoperative predictors of acute kidney injury after liver transplantation
title_short Pre- and intraoperative predictors of acute kidney injury after liver transplantation
title_sort pre- and intraoperative predictors of acute kidney injury after liver transplantation
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520778/
https://www.ncbi.nlm.nih.gov/pubmed/33024760
http://dx.doi.org/10.12998/wjcc.v8.i18.4034
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