DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions

R-loops are three-stranded structures consisting of a DNA/RNA hybrid and a displaced DNA strand. The regulatory factors required to process this fundamental genetic structure near double-strand DNA breaks (DSBs) are not well understood. We previously reported that cellular depletion of the ATP-depen...

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Detalles Bibliográficos
Autores principales: Yu, Zhenbao, Mersaoui, Sofiane Y, Guitton-Sert, Laure, Coulombe, Yan, Song, Jingwen, Masson, Jean-Yves, Richard, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520851/
https://www.ncbi.nlm.nih.gov/pubmed/33015627
http://dx.doi.org/10.1093/narcan/zcaa028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520851/
https://www.ncbi.nlm.nih.gov/pubmed/33015627
http://dx.doi.org/10.1093/narcan/zcaa028

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