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The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages

BACKGROUND: The biologic implications of delayed parenthood have been blamed for a major public health crisis in the United States, that includes high rates of neonatal morbidity and mortality (NMM). The objective of this study was to evaluate the risk of parent age on NMM and to provide results tha...

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Autor principal: Thompson, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520964/
https://www.ncbi.nlm.nih.gov/pubmed/32988379
http://dx.doi.org/10.1186/s12887-020-02341-0
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author Thompson, James A.
author_facet Thompson, James A.
author_sort Thompson, James A.
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description BACKGROUND: The biologic implications of delayed parenthood have been blamed for a major public health crisis in the United States, that includes high rates of neonatal morbidity and mortality (NMM). The objective of this study was to evaluate the risk of parent age on NMM and to provide results that can serve as a starting point for more specific mediation modeling. METHODS: Data containing approximately 15,000,000 birth records were obtained from the United States Natality database for the years 2014 to 2018. A Bayesian modeling approach was used to estimate the both the total effect and the risk adjusted for confounding between parent ages and for mediation by chromosomal disorders including Down syndrome. Outcomes included intra-hospital death and nine measures of neonatal morbidity. RESULTS: For paternal age, seven NMM (preterm birth, very preterm birth, low Apgar score, treatment with antibiotics, treatment with surfactant, prolonged ventilation, intra-hospital death) had U-shaped risk patterns, two NMM (small for gestational age, admission to neonatal intensive care) had J-shaped risk patterns, one NMM (seizures) was not significantly related to paternal age. For maternal age, three NMM (low Apgar score, treatment with antibiotics and intra-hospital death) had U-shaped risk patterns, four NMM (preterm delivery, very preterm delivery, admission to neonatal intensive care, treatment with surfactant) had J-shaped risk patterns, one NMM (small for gestational age) had a risk declining with age, one NMM (prolonged ventilation) had a risk increasing with age and one NMM (seizures) was not significantly related to maternal age. CONCLUSIONS: Both advancing maternal and paternal ages had U- or J-shaped risk patterns for neonatal morbidity and mortality.
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spelling pubmed-75209642020-09-30 The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages Thompson, James A. BMC Pediatr Research Article BACKGROUND: The biologic implications of delayed parenthood have been blamed for a major public health crisis in the United States, that includes high rates of neonatal morbidity and mortality (NMM). The objective of this study was to evaluate the risk of parent age on NMM and to provide results that can serve as a starting point for more specific mediation modeling. METHODS: Data containing approximately 15,000,000 birth records were obtained from the United States Natality database for the years 2014 to 2018. A Bayesian modeling approach was used to estimate the both the total effect and the risk adjusted for confounding between parent ages and for mediation by chromosomal disorders including Down syndrome. Outcomes included intra-hospital death and nine measures of neonatal morbidity. RESULTS: For paternal age, seven NMM (preterm birth, very preterm birth, low Apgar score, treatment with antibiotics, treatment with surfactant, prolonged ventilation, intra-hospital death) had U-shaped risk patterns, two NMM (small for gestational age, admission to neonatal intensive care) had J-shaped risk patterns, one NMM (seizures) was not significantly related to paternal age. For maternal age, three NMM (low Apgar score, treatment with antibiotics and intra-hospital death) had U-shaped risk patterns, four NMM (preterm delivery, very preterm delivery, admission to neonatal intensive care, treatment with surfactant) had J-shaped risk patterns, one NMM (small for gestational age) had a risk declining with age, one NMM (prolonged ventilation) had a risk increasing with age and one NMM (seizures) was not significantly related to maternal age. CONCLUSIONS: Both advancing maternal and paternal ages had U- or J-shaped risk patterns for neonatal morbidity and mortality. BioMed Central 2020-09-28 /pmc/articles/PMC7520964/ /pubmed/32988379 http://dx.doi.org/10.1186/s12887-020-02341-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Thompson, James A.
The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages
title The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages
title_full The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages
title_fullStr The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages
title_full_unstemmed The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages
title_short The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages
title_sort risks of advancing parental age on neonatal morbidity and mortality are u- or j-shaped for both maternal and paternal ages
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520964/
https://www.ncbi.nlm.nih.gov/pubmed/32988379
http://dx.doi.org/10.1186/s12887-020-02341-0
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