Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report

Central nervous system involvement in Hodgkin lymphoma is extremely rare, especially in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), which usually carries a favorable prognosis. Here we report a case of a young patient with NLPHL, who developed a progressive and fatal neurological deteri...

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Autores principales: Salvioni Chiabotti, Paolo, Bisig, Bettina, Cairoli, Anne, Hajdu, Steven D., Lovey, Pierre-Yves, Milowich, Dina, Ziadi, Sonia, Du Pasquier, Renaud, Brouland, Jean-Philippe, de Leval, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521157/
https://www.ncbi.nlm.nih.gov/pubmed/33042818
http://dx.doi.org/10.3389/fonc.2020.01745
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author Salvioni Chiabotti, Paolo
Bisig, Bettina
Cairoli, Anne
Hajdu, Steven D.
Lovey, Pierre-Yves
Milowich, Dina
Ziadi, Sonia
Du Pasquier, Renaud
Brouland, Jean-Philippe
de Leval, Laurence
author_facet Salvioni Chiabotti, Paolo
Bisig, Bettina
Cairoli, Anne
Hajdu, Steven D.
Lovey, Pierre-Yves
Milowich, Dina
Ziadi, Sonia
Du Pasquier, Renaud
Brouland, Jean-Philippe
de Leval, Laurence
author_sort Salvioni Chiabotti, Paolo
collection PubMed
description Central nervous system involvement in Hodgkin lymphoma is extremely rare, especially in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), which usually carries a favorable prognosis. Here we report a case of a young patient with NLPHL, who developed a progressive and fatal neurological deterioration requiring a very extensive work-up including two biopsies to obtain the diagnosis of T-cell/histiocyte-rich large B-cell lymphoma like transformation. This report, which includes post-mortem analysis, highlights the correlations between clinical, radiological, and biological data but also the difficulties encountered in reaching the correct diagnosis.
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spelling pubmed-75211572020-10-09 Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report Salvioni Chiabotti, Paolo Bisig, Bettina Cairoli, Anne Hajdu, Steven D. Lovey, Pierre-Yves Milowich, Dina Ziadi, Sonia Du Pasquier, Renaud Brouland, Jean-Philippe de Leval, Laurence Front Oncol Oncology Central nervous system involvement in Hodgkin lymphoma is extremely rare, especially in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), which usually carries a favorable prognosis. Here we report a case of a young patient with NLPHL, who developed a progressive and fatal neurological deterioration requiring a very extensive work-up including two biopsies to obtain the diagnosis of T-cell/histiocyte-rich large B-cell lymphoma like transformation. This report, which includes post-mortem analysis, highlights the correlations between clinical, radiological, and biological data but also the difficulties encountered in reaching the correct diagnosis. Frontiers Media S.A. 2020-09-14 /pmc/articles/PMC7521157/ /pubmed/33042818 http://dx.doi.org/10.3389/fonc.2020.01745 Text en Copyright © 2020 Salvioni Chiabotti, Bisig, Cairoli, Hajdu, Lovey, Milowich, Ziadi, Du Pasquier, Brouland and de Leval. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Salvioni Chiabotti, Paolo
Bisig, Bettina
Cairoli, Anne
Hajdu, Steven D.
Lovey, Pierre-Yves
Milowich, Dina
Ziadi, Sonia
Du Pasquier, Renaud
Brouland, Jean-Philippe
de Leval, Laurence
Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report
title Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report
title_full Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report
title_fullStr Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report
title_full_unstemmed Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report
title_short Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report
title_sort meningeal relapse of nodular lymphocyte predominant hodgkin lymphoma transformed to t-cell/histiocyte-rich large b-cell lymphoma: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521157/
https://www.ncbi.nlm.nih.gov/pubmed/33042818
http://dx.doi.org/10.3389/fonc.2020.01745
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