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The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity

BACKGROUND: MicroRNA‐126 (miR‐126) has been investigated in autoimmune diseases and organ failures, whereas its implication in sepsis is rarely reported. Our study initially explored the value of miR‐126 in diagnosing sepsis and predicting disease severity, degree of inflammation, and mortality. MET...

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Autores principales: Lin, Run, Hu, Haiyan, Li, Lehui, Chen, Gengqian, Luo, Lingqing, Rao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521265/
https://www.ncbi.nlm.nih.gov/pubmed/32484987
http://dx.doi.org/10.1002/jcla.23408
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author Lin, Run
Hu, Haiyan
Li, Lehui
Chen, Gengqian
Luo, Lingqing
Rao, Ping
author_facet Lin, Run
Hu, Haiyan
Li, Lehui
Chen, Gengqian
Luo, Lingqing
Rao, Ping
author_sort Lin, Run
collection PubMed
description BACKGROUND: MicroRNA‐126 (miR‐126) has been investigated in autoimmune diseases and organ failures, whereas its implication in sepsis is rarely reported. Our study initially explored the value of miR‐126 in diagnosing sepsis and predicting disease severity, degree of inflammation, and mortality. METHODS: Totally, 208 sepsis patients and 210 healthy controls were enrolled; then, their plasma samples were collected for detecting circulating miR‐126 by quantitative polymerase chain reaction. For sepsis patients, their cytokine levels in plasma samples were detected by enzyme‐linked immunosorbent assay. RESULTS: miR‐126 was upregulated in sepsis patients compared with healthy controls, and it was of certain value in distinguishing sepsis patients from healthy controls (AUC: 0.726 (95% CI: 0.678‐0.774)). miR‐126 expression was positively correlated with acute physiology and chronic health evaluation II score, serum creatinine, and C‐reactive protein but not albumin or white blood cell count in sepsis patients. Regarding cytokines, miR‐126 was positively correlated with tumor necrosis factor‐α, interleukin (IL)‐6, and IL‐8, but negatively correlated with IL‐10 in sepsis patients. As for mortality, miR‐126 expression was higher in deaths compared with survivors, and ROC curve displayed that it could predict mortality of sepsis patients to some extent with AUC of 0.619 (95% CI: 0.533‐0.705). CONCLUSION: miR‐126 potentially serves as an assistant diagnostic and prognostic biomarker for sepsis.
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spelling pubmed-75212652020-09-30 The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity Lin, Run Hu, Haiyan Li, Lehui Chen, Gengqian Luo, Lingqing Rao, Ping J Clin Lab Anal Research Articles BACKGROUND: MicroRNA‐126 (miR‐126) has been investigated in autoimmune diseases and organ failures, whereas its implication in sepsis is rarely reported. Our study initially explored the value of miR‐126 in diagnosing sepsis and predicting disease severity, degree of inflammation, and mortality. METHODS: Totally, 208 sepsis patients and 210 healthy controls were enrolled; then, their plasma samples were collected for detecting circulating miR‐126 by quantitative polymerase chain reaction. For sepsis patients, their cytokine levels in plasma samples were detected by enzyme‐linked immunosorbent assay. RESULTS: miR‐126 was upregulated in sepsis patients compared with healthy controls, and it was of certain value in distinguishing sepsis patients from healthy controls (AUC: 0.726 (95% CI: 0.678‐0.774)). miR‐126 expression was positively correlated with acute physiology and chronic health evaluation II score, serum creatinine, and C‐reactive protein but not albumin or white blood cell count in sepsis patients. Regarding cytokines, miR‐126 was positively correlated with tumor necrosis factor‐α, interleukin (IL)‐6, and IL‐8, but negatively correlated with IL‐10 in sepsis patients. As for mortality, miR‐126 expression was higher in deaths compared with survivors, and ROC curve displayed that it could predict mortality of sepsis patients to some extent with AUC of 0.619 (95% CI: 0.533‐0.705). CONCLUSION: miR‐126 potentially serves as an assistant diagnostic and prognostic biomarker for sepsis. John Wiley and Sons Inc. 2020-06-02 /pmc/articles/PMC7521265/ /pubmed/32484987 http://dx.doi.org/10.1002/jcla.23408 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Lin, Run
Hu, Haiyan
Li, Lehui
Chen, Gengqian
Luo, Lingqing
Rao, Ping
The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
title The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
title_full The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
title_fullStr The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
title_full_unstemmed The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
title_short The potential of microRNA‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
title_sort potential of microrna‐126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521265/
https://www.ncbi.nlm.nih.gov/pubmed/32484987
http://dx.doi.org/10.1002/jcla.23408
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