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Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers

Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non‐coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a vari...

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Autores principales: Wang, Xiao, Xie, Haiyun, Ying, Yufan, Chen, Danni, Li, Jiangfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521283/
https://www.ncbi.nlm.nih.gov/pubmed/32808488
http://dx.doi.org/10.1111/jcmm.15750
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author Wang, Xiao
Xie, Haiyun
Ying, Yufan
Chen, Danni
Li, Jiangfeng
author_facet Wang, Xiao
Xie, Haiyun
Ying, Yufan
Chen, Danni
Li, Jiangfeng
author_sort Wang, Xiao
collection PubMed
description Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non‐coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a variety of physiological processes and in disease progression, especially in human cancers. Among the various RNA modifications, m(6)A is the most common. The function of m(6)A modifications is mainly regulated by 3 types of proteins: m(6)A methyltransferases (writers), m(6)A demethylases (erasers) and m(6)A‐binding proteins (readers). In this review, we focus on RNA m(6)A modification and its relationship with urological cancers, particularly focusing on its roles and potential clinical applications.
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spelling pubmed-75212832020-09-30 Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers Wang, Xiao Xie, Haiyun Ying, Yufan Chen, Danni Li, Jiangfeng J Cell Mol Med Reviews Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non‐coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a variety of physiological processes and in disease progression, especially in human cancers. Among the various RNA modifications, m(6)A is the most common. The function of m(6)A modifications is mainly regulated by 3 types of proteins: m(6)A methyltransferases (writers), m(6)A demethylases (erasers) and m(6)A‐binding proteins (readers). In this review, we focus on RNA m(6)A modification and its relationship with urological cancers, particularly focusing on its roles and potential clinical applications. John Wiley and Sons Inc. 2020-08-17 2020-09 /pmc/articles/PMC7521283/ /pubmed/32808488 http://dx.doi.org/10.1111/jcmm.15750 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Wang, Xiao
Xie, Haiyun
Ying, Yufan
Chen, Danni
Li, Jiangfeng
Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
title Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
title_full Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
title_fullStr Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
title_full_unstemmed Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
title_short Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
title_sort roles of n(6)‐methyladenosine (m(6)a) rna modifications in urological cancers
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521283/
https://www.ncbi.nlm.nih.gov/pubmed/32808488
http://dx.doi.org/10.1111/jcmm.15750
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