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Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non‐coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a vari...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521283/ https://www.ncbi.nlm.nih.gov/pubmed/32808488 http://dx.doi.org/10.1111/jcmm.15750 |
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author | Wang, Xiao Xie, Haiyun Ying, Yufan Chen, Danni Li, Jiangfeng |
author_facet | Wang, Xiao Xie, Haiyun Ying, Yufan Chen, Danni Li, Jiangfeng |
author_sort | Wang, Xiao |
collection | PubMed |
description | Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non‐coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a variety of physiological processes and in disease progression, especially in human cancers. Among the various RNA modifications, m(6)A is the most common. The function of m(6)A modifications is mainly regulated by 3 types of proteins: m(6)A methyltransferases (writers), m(6)A demethylases (erasers) and m(6)A‐binding proteins (readers). In this review, we focus on RNA m(6)A modification and its relationship with urological cancers, particularly focusing on its roles and potential clinical applications. |
format | Online Article Text |
id | pubmed-7521283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75212832020-09-30 Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers Wang, Xiao Xie, Haiyun Ying, Yufan Chen, Danni Li, Jiangfeng J Cell Mol Med Reviews Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non‐coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a variety of physiological processes and in disease progression, especially in human cancers. Among the various RNA modifications, m(6)A is the most common. The function of m(6)A modifications is mainly regulated by 3 types of proteins: m(6)A methyltransferases (writers), m(6)A demethylases (erasers) and m(6)A‐binding proteins (readers). In this review, we focus on RNA m(6)A modification and its relationship with urological cancers, particularly focusing on its roles and potential clinical applications. John Wiley and Sons Inc. 2020-08-17 2020-09 /pmc/articles/PMC7521283/ /pubmed/32808488 http://dx.doi.org/10.1111/jcmm.15750 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Wang, Xiao Xie, Haiyun Ying, Yufan Chen, Danni Li, Jiangfeng Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers |
title | Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers |
title_full | Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers |
title_fullStr | Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers |
title_full_unstemmed | Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers |
title_short | Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers |
title_sort | roles of n(6)‐methyladenosine (m(6)a) rna modifications in urological cancers |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521283/ https://www.ncbi.nlm.nih.gov/pubmed/32808488 http://dx.doi.org/10.1111/jcmm.15750 |
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