CD8(+) T‐cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations

BACKGROUND: Dyskeratosis congenita (DC) is a syndrome resulting from defective telomere maintenance. Immunodeficiency associated with DC can cause significant morbidity and lead to premature mortality, but the immunological characteristics and molecular hallmark of DC patients, especially young pati...

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Detalles Bibliográficos
Autores principales: Zeng, Ting, Lv, Ge, Chen, Xuemei, Yang, Lu, Zhou, Lina, Dou, Ying, Tang, Xuemei, Yang, Jun, An, Yunfei, Zhao, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521304/
https://www.ncbi.nlm.nih.gov/pubmed/32452087
http://dx.doi.org/10.1002/jcla.23375

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