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Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth
Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521331/ https://www.ncbi.nlm.nih.gov/pubmed/32744427 http://dx.doi.org/10.1111/jcmm.15648 |
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author | Zhou, Li‐Yu Han, Feng Qi, Shi‐Bin Ma, Jin‐Jin Ma, Yan‐Xia Xie, Ji‐Le Zhang, Hong‐Cheng Fu, Xin‐Ya Chen, Jian‐Quan Li, Bin Yang, Hui‐Lin Zhou, Feng Saijilafu, |
author_facet | Zhou, Li‐Yu Han, Feng Qi, Shi‐Bin Ma, Jin‐Jin Ma, Yan‐Xia Xie, Ji‐Le Zhang, Hong‐Cheng Fu, Xin‐Ya Chen, Jian‐Quan Li, Bin Yang, Hui‐Lin Zhou, Feng Saijilafu, |
author_sort | Zhou, Li‐Yu |
collection | PubMed |
description | Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4‐positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4‐positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4‐positive neurons. |
format | Online Article Text |
id | pubmed-7521331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75213312020-10-02 Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth Zhou, Li‐Yu Han, Feng Qi, Shi‐Bin Ma, Jin‐Jin Ma, Yan‐Xia Xie, Ji‐Le Zhang, Hong‐Cheng Fu, Xin‐Ya Chen, Jian‐Quan Li, Bin Yang, Hui‐Lin Zhou, Feng Saijilafu, J Cell Mol Med Short Communications Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4‐positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4‐positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4‐positive neurons. John Wiley and Sons Inc. 2020-08-03 2020-09 /pmc/articles/PMC7521331/ /pubmed/32744427 http://dx.doi.org/10.1111/jcmm.15648 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communications Zhou, Li‐Yu Han, Feng Qi, Shi‐Bin Ma, Jin‐Jin Ma, Yan‐Xia Xie, Ji‐Le Zhang, Hong‐Cheng Fu, Xin‐Ya Chen, Jian‐Quan Li, Bin Yang, Hui‐Lin Zhou, Feng Saijilafu, Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth |
title | Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth |
title_full | Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth |
title_fullStr | Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth |
title_full_unstemmed | Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth |
title_short | Inhibition of PTEN activity promotes IB4‐positive sensory neuronal axon growth |
title_sort | inhibition of pten activity promotes ib4‐positive sensory neuronal axon growth |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521331/ https://www.ncbi.nlm.nih.gov/pubmed/32744427 http://dx.doi.org/10.1111/jcmm.15648 |
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