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Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves as a central cue for...

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Detalles Bibliográficos
Autores principales: Ha, Connie W.Y., Martin, Anthony, Sepich-Poore, Gregory D., Shi, Baochen, Wang, Yizhou, Gouin, Kenneth, Humphrey, Gregory, Sanders, Karenina, Ratnayake, Yasiru, Chan, Kelvin S.L., Hendrick, Gustaf, Caldera, J.R., Arias, Christian, Moskowitz, Jacob E., Ho Sui, Shannan J., Yang, Shaohong, Underhill, David, Brady, Matthew J., Knott, Simon, Kaihara, Kelly, Steinbaugh, Michael J., Li, Huiying, McGovern, Dermot P.B., Knight, Rob, Fleshner, Phillip, Devkota, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521382/
https://www.ncbi.nlm.nih.gov/pubmed/32991841
http://dx.doi.org/10.1016/j.cell.2020.09.009