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Insulin-receptor substrate 1 protects against injury in endothelial cell models of ox-LDL-induced atherosclerosis by inhibiting ER stress/oxidative stress-mediated apoptosis and activating the Akt/FoxO1 signaling pathway

Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell (EC) injury is a risk factor for atherosclerosis. Therefore, the present study aimed to investigate the effects of insulin-receptor substrate 1 (IRS-1) on injury to ox-LDL-exposed ECs. For this purpose, thoracic aorta tissues were is...

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Detalles Bibliográficos
Autores principales:	Liu, Juan, Yi, Xu, Tao, Yuan, Wang, Yanjiang, Xu, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521546/ https://www.ncbi.nlm.nih.gov/pubmed/33000267 http://dx.doi.org/10.3892/ijmm.2020.4728

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