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Animal and human RNA viruses: genetic variability and ability to overcome vaccines

RNA viruses, in general, exhibit high mutation rates; this is mainly due to the low fidelity displayed by the RNA-dependent polymerases required for their replication that lack the proofreading machinery to correct misincorporated nucleotides and produce high mutation rates. This lack of replication...

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Detalles Bibliográficos
Autores principales: Villa, T. G., Abril, Ana G., Sánchez, S., de Miguel, T., Sánchez-Pérez, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521576/
https://www.ncbi.nlm.nih.gov/pubmed/32989475
http://dx.doi.org/10.1007/s00203-020-02040-5