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Structural analysis of the LDL receptor–interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site
Hepatic abundance of the low-density lipoprotein receptor (LDLR) is a critical determinant of circulating plasma LDL cholesterol levels and hence development of coronary artery disease. The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) specifically promotes ubiquitinati...
Autores principales: | Martinelli, Luca, Adamopoulos, Athanassios, Johansson, Patrik, Wan, Paul T., Gunnarsson, Jenny, Guo, Hongwei, Boyd, Helen, Zelcer, Noam, Sixma, Titia K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521653/ https://www.ncbi.nlm.nih.gov/pubmed/32727844 http://dx.doi.org/10.1074/jbc.RA120.014349 |
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