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Structural analysis of the LDL receptor–interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site

Hepatic abundance of the low-density lipoprotein receptor (LDLR) is a critical determinant of circulating plasma LDL cholesterol levels and hence development of coronary artery disease. The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) specifically promotes ubiquitinati...

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Detalles Bibliográficos
Autores principales:	Martinelli, Luca, Adamopoulos, Athanassios, Johansson, Patrik, Wan, Paul T., Gunnarsson, Jenny, Guo, Hongwei, Boyd, Helen, Zelcer, Noam, Sixma, Titia K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521653/ https://www.ncbi.nlm.nih.gov/pubmed/32727844 http://dx.doi.org/10.1074/jbc.RA120.014349

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