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Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders

This study assessed the interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and the interactions of gene and physical activity on handgrip strength, arm muscle mass-adjusted handgrip (armGrip), gait speed (GS), timed up and go (TUG), and leg press strength (LPS). Nine single nucleotide polym...

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Autores principales: Li, Tsai-Chung, Wu, Ching-Wei, Li, Chia-Ing, Wu, Fang-Yang, Liao, Li-Na, Liu, Chiu-Shong, Lin, Chih-Hsueh, Wang, Mu-Cyun, Yang, Chuan-Wei, Lin, Cheng-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521683/
https://www.ncbi.nlm.nih.gov/pubmed/32986769
http://dx.doi.org/10.1371/journal.pone.0239530
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author Li, Tsai-Chung
Wu, Ching-Wei
Li, Chia-Ing
Wu, Fang-Yang
Liao, Li-Na
Liu, Chiu-Shong
Lin, Chih-Hsueh
Wang, Mu-Cyun
Yang, Chuan-Wei
Lin, Cheng-Chieh
author_facet Li, Tsai-Chung
Wu, Ching-Wei
Li, Chia-Ing
Wu, Fang-Yang
Liao, Li-Na
Liu, Chiu-Shong
Lin, Chih-Hsueh
Wang, Mu-Cyun
Yang, Chuan-Wei
Lin, Cheng-Chieh
author_sort Li, Tsai-Chung
collection PubMed
description This study assessed the interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and the interactions of gene and physical activity on handgrip strength, arm muscle mass-adjusted handgrip (armGrip), gait speed (GS), timed up and go (TUG), and leg press strength (LPS). Nine single nucleotide polymorphisms (SNPs) containing three IGF-1 SNPs (rs6214, rs5742692, and rs35767), two AKT2 SNPs (rs892119 and rs35817154), two FOXO1 SNPs (rs17446593 and rs10507486), and two FOXO3 SNPs (rs9480865 and rs2153960) were genotyped in 472 unrelated elders with a mean age of 73.8 years. We observed significant interactions of IGF-1 SNP rs6214 and rs35767 with regular physical activity on TUG and GS; and AKT2 SNP rs892119 and FOXO3 SNP rs9480865 with regular physical activity on armGrip. Genotype GG of IGF-1 rs6214 and rs35767 in individuals without regular physical activity had poor performance in TUG and GS, as well as GG of AKT2 rs892119 decreased armGrip in individuals without regular physical activity. After FDR adjustment, no significant gene–gene interactions were found. A sedentary lifestyle may increase the risk of impairing physical performance and regular physical activity is a remedy for sarcopenia, even a little regular physical activity can overcome carrying some risk alleles in this pathway.
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spelling pubmed-75216832020-10-06 Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders Li, Tsai-Chung Wu, Ching-Wei Li, Chia-Ing Wu, Fang-Yang Liao, Li-Na Liu, Chiu-Shong Lin, Chih-Hsueh Wang, Mu-Cyun Yang, Chuan-Wei Lin, Cheng-Chieh PLoS One Research Article This study assessed the interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and the interactions of gene and physical activity on handgrip strength, arm muscle mass-adjusted handgrip (armGrip), gait speed (GS), timed up and go (TUG), and leg press strength (LPS). Nine single nucleotide polymorphisms (SNPs) containing three IGF-1 SNPs (rs6214, rs5742692, and rs35767), two AKT2 SNPs (rs892119 and rs35817154), two FOXO1 SNPs (rs17446593 and rs10507486), and two FOXO3 SNPs (rs9480865 and rs2153960) were genotyped in 472 unrelated elders with a mean age of 73.8 years. We observed significant interactions of IGF-1 SNP rs6214 and rs35767 with regular physical activity on TUG and GS; and AKT2 SNP rs892119 and FOXO3 SNP rs9480865 with regular physical activity on armGrip. Genotype GG of IGF-1 rs6214 and rs35767 in individuals without regular physical activity had poor performance in TUG and GS, as well as GG of AKT2 rs892119 decreased armGrip in individuals without regular physical activity. After FDR adjustment, no significant gene–gene interactions were found. A sedentary lifestyle may increase the risk of impairing physical performance and regular physical activity is a remedy for sarcopenia, even a little regular physical activity can overcome carrying some risk alleles in this pathway. Public Library of Science 2020-09-28 /pmc/articles/PMC7521683/ /pubmed/32986769 http://dx.doi.org/10.1371/journal.pone.0239530 Text en © 2020 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Tsai-Chung
Wu, Ching-Wei
Li, Chia-Ing
Wu, Fang-Yang
Liao, Li-Na
Liu, Chiu-Shong
Lin, Chih-Hsueh
Wang, Mu-Cyun
Yang, Chuan-Wei
Lin, Cheng-Chieh
Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
title Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
title_full Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
title_fullStr Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
title_full_unstemmed Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
title_short Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders
title_sort interactions among igf-1, akt2, foxo1, and foxo3 variations and between genes and physical activities on physical performance in community-dwelling elders
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521683/
https://www.ncbi.nlm.nih.gov/pubmed/32986769
http://dx.doi.org/10.1371/journal.pone.0239530
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