Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging

Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase reporter, we were able to monitor tumor burden non-...

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Detalles Bibliográficos
Autores principales: Yong, Courtney, Moose, Devon L., Bannick, Nadine, Gutierrez, Wade R., Vanneste, Marion, Svensson, Robert, Breheny, Patrick, Brown, James A., Dodd, Rebecca D., Cohen, Michael B., Henry, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521703/
https://www.ncbi.nlm.nih.gov/pubmed/32986721
http://dx.doi.org/10.1371/journal.pone.0232807

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