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Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups

A novel methodology to access alkynyl nucleoside analogues is elaborated. Highly fluorescent 5-alkynylfuropyrimidines were synthesized (97-46%) and their antiviral properties investigated in vitro. Regiochemistry of the functionalization was achieved with the aid of 5-endo-dig electrophilic halocycl...

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Detalles Bibliográficos
Autores principales:	Kaczmarek, Renata, Twardy, Dylan J., Olson, Trevor L., Korczyński, Dariusz, Andrei, Graciela, Snoeck, Robert, Dolot, Rafał, Wheeler, Kraig A., Dembinski, Roman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521880/ https://www.ncbi.nlm.nih.gov/pubmed/33039724 http://dx.doi.org/10.1016/j.ejmech.2020.112884

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