Cargando…
A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection
Hypoparathyroidism is usually caused by postsurgical or autoimmune damage to the parathyroid gland. We present the case of a 46-year-old Hispanic male with no significant past medical history who was admitted to the hospital with hypoxic respiratory failure due to coronavirus disease 2019 (COVID-19)...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522187/ https://www.ncbi.nlm.nih.gov/pubmed/33005518 http://dx.doi.org/10.7759/cureus.10097 |
_version_ | 1783588124029353984 |
---|---|
author | Elkattawy, Sherif Alyacoub, Ramez Ayad, Sarah Pandya, Manthan Eckman, Ari |
author_facet | Elkattawy, Sherif Alyacoub, Ramez Ayad, Sarah Pandya, Manthan Eckman, Ari |
author_sort | Elkattawy, Sherif |
collection | PubMed |
description | Hypoparathyroidism is usually caused by postsurgical or autoimmune damage to the parathyroid gland. We present the case of a 46-year-old Hispanic male with no significant past medical history who was admitted to the hospital with hypoxic respiratory failure due to coronavirus disease 2019 (COVID-19) infection and had a prolonged hospital course. He was incidentally found to have hyperphosphatemia and low parathyroid hormone (PTH) levels. During the second month of hospitalization, his phosphorus levels rose to 6.9 mg/dL (normal range: 2.4-4.7 mg/dl). His PTH levels were found to be at 8 pg/mL. Vitamin D levels obtained were also low (7 ng/dL), phosphorus was at 5.8 mg/dL with albumin of 2.9 g/dL, and calcium level was normal at 9.2 mg/dl. Parathyroid hormone-related peptide (PTHrP) level was low at 10. Malignancy and genetic causes were ruled out. The patient was started on 50,000 units of ergocalciferol once a week. He was also started on calcium acetate 1,334 mg three times a day for hyperphosphatemia. Phosphorus levels remained elevated, and sevelamer was added on discharge after he was weaned off oxygen and cleared by physical therapy. No explanation for persistent hyperphosphatemia and hypoparathyroidism was found. To date, there have been some reports linking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to widespread tissue injury; however, there have been no reports so far on the effect of the parathyroid gland. Further studies are necessary to elaborate and to confirm the causative relationship between SARS-CoV-2 and hyperphosphatemia. |
format | Online Article Text |
id | pubmed-7522187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-75221872020-09-30 A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection Elkattawy, Sherif Alyacoub, Ramez Ayad, Sarah Pandya, Manthan Eckman, Ari Cureus Endocrinology/Diabetes/Metabolism Hypoparathyroidism is usually caused by postsurgical or autoimmune damage to the parathyroid gland. We present the case of a 46-year-old Hispanic male with no significant past medical history who was admitted to the hospital with hypoxic respiratory failure due to coronavirus disease 2019 (COVID-19) infection and had a prolonged hospital course. He was incidentally found to have hyperphosphatemia and low parathyroid hormone (PTH) levels. During the second month of hospitalization, his phosphorus levels rose to 6.9 mg/dL (normal range: 2.4-4.7 mg/dl). His PTH levels were found to be at 8 pg/mL. Vitamin D levels obtained were also low (7 ng/dL), phosphorus was at 5.8 mg/dL with albumin of 2.9 g/dL, and calcium level was normal at 9.2 mg/dl. Parathyroid hormone-related peptide (PTHrP) level was low at 10. Malignancy and genetic causes were ruled out. The patient was started on 50,000 units of ergocalciferol once a week. He was also started on calcium acetate 1,334 mg three times a day for hyperphosphatemia. Phosphorus levels remained elevated, and sevelamer was added on discharge after he was weaned off oxygen and cleared by physical therapy. No explanation for persistent hyperphosphatemia and hypoparathyroidism was found. To date, there have been some reports linking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to widespread tissue injury; however, there have been no reports so far on the effect of the parathyroid gland. Further studies are necessary to elaborate and to confirm the causative relationship between SARS-CoV-2 and hyperphosphatemia. Cureus 2020-08-28 /pmc/articles/PMC7522187/ /pubmed/33005518 http://dx.doi.org/10.7759/cureus.10097 Text en Copyright © 2020, Elkattawy et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Elkattawy, Sherif Alyacoub, Ramez Ayad, Sarah Pandya, Manthan Eckman, Ari A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection |
title | A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection |
title_full | A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection |
title_fullStr | A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection |
title_full_unstemmed | A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection |
title_short | A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection |
title_sort | novel case of hypoparathyroidism secondary to sars-cov-2 infection |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522187/ https://www.ncbi.nlm.nih.gov/pubmed/33005518 http://dx.doi.org/10.7759/cureus.10097 |
work_keys_str_mv | AT elkattawysherif anovelcaseofhypoparathyroidismsecondarytosarscov2infection AT alyacoubramez anovelcaseofhypoparathyroidismsecondarytosarscov2infection AT ayadsarah anovelcaseofhypoparathyroidismsecondarytosarscov2infection AT pandyamanthan anovelcaseofhypoparathyroidismsecondarytosarscov2infection AT eckmanari anovelcaseofhypoparathyroidismsecondarytosarscov2infection AT elkattawysherif novelcaseofhypoparathyroidismsecondarytosarscov2infection AT alyacoubramez novelcaseofhypoparathyroidismsecondarytosarscov2infection AT ayadsarah novelcaseofhypoparathyroidismsecondarytosarscov2infection AT pandyamanthan novelcaseofhypoparathyroidismsecondarytosarscov2infection AT eckmanari novelcaseofhypoparathyroidismsecondarytosarscov2infection |