Impairment of cerebellar long-term depression and GABAergic transmission in prion protein deficient mice ectopically expressing PrPLP/Dpl

Prion protein (PrP(C)) knockout mice, named as the “Ngsk” strain (Ngsk Prnp(0/0) mice), show late-onset cerebellar Purkinje cell (PC) degeneration because of ectopic overexpression of PrP(C)-like protein (PrPLP/Dpl). Our previous study indicated that the mutant mice also exhibited alterations in cer...

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Detalles Bibliográficos
Autores principales: Kishimoto, Yasushi, Hirono, Moritoshi, Atarashi, Ryuichiro, Sakaguchi, Suehiro, Yoshioka, Tohru, Katamine, Shigeru, Kirino, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522223/
https://www.ncbi.nlm.nih.gov/pubmed/32985542
http://dx.doi.org/10.1038/s41598-020-72753-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522223/
https://www.ncbi.nlm.nih.gov/pubmed/32985542
http://dx.doi.org/10.1038/s41598-020-72753-6

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