The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel–Lindau tumor suppressor

Mutations of the von Hippel–Lindau (pVHL) tumor suppressor are causative of a familiar predisposition to develop different types of cancer. pVHL is mainly known for its role in regulating hypoxia-inducible factor 1 α (HIF-1α) degradation, thus modulating the hypoxia response. There are different pVH...

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Detalles Bibliográficos
Autores principales: Falconieri, Antonella, Minervini, Giovanni, Bortolotto, Raissa, Piovesan, Damiano, Lopreiato, Raffaele, Sartori, Geppo, Pennuto, Maria, Tosatto, Silvio C. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522254/
https://www.ncbi.nlm.nih.gov/pubmed/32985545
http://dx.doi.org/10.1038/s41598-020-72683-3

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