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Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception

BACKGROUND: Long-term use of morphine induces antinociceptive tolerance and limits its clinical efficacy. Neuroinflammation in the spinal cord is thought to play a pivotal role in the development of morphine tolerance. Toll-like receptor 4 (TLR4) and P2X7 receptor (P2X7R) are key modulators of neuro...

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Detalles Bibliográficos
Autores principales:	Wang, Haiyan, Zhang, Yu, Ma, Xiaqing, Wang, Wenying, Xu, Xiaotao, Huang, Min, Xu, Liang, Shi, Haibo, Yuan, Tifei, Jiang, Wei, Wang, Aizhong, Xu, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522404/ https://www.ncbi.nlm.nih.gov/pubmed/33061523 http://dx.doi.org/10.2147/JIR.S266995

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