Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families

PURPOSE: There is increasing evidence indicating that considerable fractions of cases of SARS-CoV-2 infection are asymptomatic. We traced three asymptomatic clusters to investigate the infectivity of subclinical cases of coronavirus disease 2019 (COVID-19). PATIENTS AND METHODS: Three medical staff...

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Autores principales: Zhang, Xian, Chen, Liting, Wei, Jia, Zhou, Jianfeng, Cao, Yang, Wang, Gaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522516/
https://www.ncbi.nlm.nih.gov/pubmed/33061473
http://dx.doi.org/10.2147/IDR.S261304
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author Zhang, Xian
Chen, Liting
Wei, Jia
Zhou, Jianfeng
Cao, Yang
Wang, Gaoxiang
author_facet Zhang, Xian
Chen, Liting
Wei, Jia
Zhou, Jianfeng
Cao, Yang
Wang, Gaoxiang
author_sort Zhang, Xian
collection PubMed
description PURPOSE: There is increasing evidence indicating that considerable fractions of cases of SARS-CoV-2 infection are asymptomatic. We traced three asymptomatic clusters to investigate the infectivity of subclinical cases of coronavirus disease 2019 (COVID-19). PATIENTS AND METHODS: Three medical staff who were asymptomatic were diagnosed with coronavirus disease 2019 by serological tests. Their close contacts were systematically evaluated based on COVID-19-related symptoms, nucleic acid tests, serological tests, and chest computed tomography (CT) as needed to determine if they were infected by SARS-CoV-2. RESULTS: None of the staff’s close contacts, including 10 family members, were infected by the indexes, even though no protective measures were taken. CONCLUSION: The infectivity of asymptomatic subclinical infection patients of coronavirus disease 2019 seems to be low.
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spelling pubmed-75225162020-10-14 Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families Zhang, Xian Chen, Liting Wei, Jia Zhou, Jianfeng Cao, Yang Wang, Gaoxiang Infect Drug Resist Short Report PURPOSE: There is increasing evidence indicating that considerable fractions of cases of SARS-CoV-2 infection are asymptomatic. We traced three asymptomatic clusters to investigate the infectivity of subclinical cases of coronavirus disease 2019 (COVID-19). PATIENTS AND METHODS: Three medical staff who were asymptomatic were diagnosed with coronavirus disease 2019 by serological tests. Their close contacts were systematically evaluated based on COVID-19-related symptoms, nucleic acid tests, serological tests, and chest computed tomography (CT) as needed to determine if they were infected by SARS-CoV-2. RESULTS: None of the staff’s close contacts, including 10 family members, were infected by the indexes, even though no protective measures were taken. CONCLUSION: The infectivity of asymptomatic subclinical infection patients of coronavirus disease 2019 seems to be low. Dove 2020-09-24 /pmc/articles/PMC7522516/ /pubmed/33061473 http://dx.doi.org/10.2147/IDR.S261304 Text en © 2020 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Short Report
Zhang, Xian
Chen, Liting
Wei, Jia
Zhou, Jianfeng
Cao, Yang
Wang, Gaoxiang
Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families
title Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families
title_full Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families
title_fullStr Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families
title_full_unstemmed Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families
title_short Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families
title_sort asymptomatic subclinical cases of coronavirus disease 2019 without viral transmission in three independent families
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522516/
https://www.ncbi.nlm.nih.gov/pubmed/33061473
http://dx.doi.org/10.2147/IDR.S261304
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