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Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study
BACKGROUND: Since its discovery in Wuhan, China in December of 2019, the novel coronavirus has progressed to become one of the worst pandemics seen in the last 100 years. Recently, there has been an increased interest in the hepatic manifestations of coronavirus disease 19 (COVID-19). AIM: To descri...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522557/ https://www.ncbi.nlm.nih.gov/pubmed/33033568 http://dx.doi.org/10.4254/wjh.v12.i9.619 |
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author | Suresh Kumar, Vishnu Charan Harne, Prateek Suresh Mukherjee, Samiran Gupta, Kashvi Masood, Umair Sharma, Anuj Vikrant Lamichhane, Jivan Dhamoon, Amit Singh Sapkota, Bishnu |
author_facet | Suresh Kumar, Vishnu Charan Harne, Prateek Suresh Mukherjee, Samiran Gupta, Kashvi Masood, Umair Sharma, Anuj Vikrant Lamichhane, Jivan Dhamoon, Amit Singh Sapkota, Bishnu |
author_sort | Suresh Kumar, Vishnu Charan |
collection | PubMed |
description | BACKGROUND: Since its discovery in Wuhan, China in December of 2019, the novel coronavirus has progressed to become one of the worst pandemics seen in the last 100 years. Recently, there has been an increased interest in the hepatic manifestations of coronavirus disease 19 (COVID-19). AIM: To describe the demographic and clinical characteristics of COVID-19 positive patients and study the association between transaminitis and all-cause mortality. METHODS: This is a descriptive retrospective cohort study of 130 consecutive patients with a positive COVID PCR test admitted between March 16, 2020 to May 14, 2020 at a tertiary care University-based medical center. The Wilcoxon-rank sum test and paired t-test were used for comparing non-parametric and parametric continuous variables respectively and a multivariable logistic regression models to study the association between transaminitis and mortality using SAS version 9.4 (SAS Institute, Cary, NC, United States). RESULTS: Out of the 130 patients, 73 (56%) patients were found to have transaminitis and 57 (44%) did not. When compared to patients without transaminitis, the transaminitis group was found to have a higher median body mass index (30.2 kg/m(2) vs 27.3 kg/m(2), P = 0.04). In the multivariate analysis those with transaminitis were found to have 3.4 times higher odds of dying as compared to those without transaminitis adjusting for gender, the Age-adjusted Charlson Comorbidity Index and admission to the intensive care unit (P = 0.03). CONCLUSION: Our study showed that transaminitis on admission was associated with severe clinical outcomes such as admission to the intensive care unit, need for mechanical ventilation, and mortality. |
format | Online Article Text |
id | pubmed-7522557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-75225572020-10-07 Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study Suresh Kumar, Vishnu Charan Harne, Prateek Suresh Mukherjee, Samiran Gupta, Kashvi Masood, Umair Sharma, Anuj Vikrant Lamichhane, Jivan Dhamoon, Amit Singh Sapkota, Bishnu World J Hepatol Retrospective Cohort Study BACKGROUND: Since its discovery in Wuhan, China in December of 2019, the novel coronavirus has progressed to become one of the worst pandemics seen in the last 100 years. Recently, there has been an increased interest in the hepatic manifestations of coronavirus disease 19 (COVID-19). AIM: To describe the demographic and clinical characteristics of COVID-19 positive patients and study the association between transaminitis and all-cause mortality. METHODS: This is a descriptive retrospective cohort study of 130 consecutive patients with a positive COVID PCR test admitted between March 16, 2020 to May 14, 2020 at a tertiary care University-based medical center. The Wilcoxon-rank sum test and paired t-test were used for comparing non-parametric and parametric continuous variables respectively and a multivariable logistic regression models to study the association between transaminitis and mortality using SAS version 9.4 (SAS Institute, Cary, NC, United States). RESULTS: Out of the 130 patients, 73 (56%) patients were found to have transaminitis and 57 (44%) did not. When compared to patients without transaminitis, the transaminitis group was found to have a higher median body mass index (30.2 kg/m(2) vs 27.3 kg/m(2), P = 0.04). In the multivariate analysis those with transaminitis were found to have 3.4 times higher odds of dying as compared to those without transaminitis adjusting for gender, the Age-adjusted Charlson Comorbidity Index and admission to the intensive care unit (P = 0.03). CONCLUSION: Our study showed that transaminitis on admission was associated with severe clinical outcomes such as admission to the intensive care unit, need for mechanical ventilation, and mortality. Baishideng Publishing Group Inc 2020-09-27 2020-09-27 /pmc/articles/PMC7522557/ /pubmed/33033568 http://dx.doi.org/10.4254/wjh.v12.i9.619 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Cohort Study Suresh Kumar, Vishnu Charan Harne, Prateek Suresh Mukherjee, Samiran Gupta, Kashvi Masood, Umair Sharma, Anuj Vikrant Lamichhane, Jivan Dhamoon, Amit Singh Sapkota, Bishnu Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study |
title | Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study |
title_full | Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study |
title_fullStr | Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study |
title_full_unstemmed | Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study |
title_short | Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study |
title_sort | transaminitis is an indicator of mortality in patients with covid-19: a retrospective cohort study |
topic | Retrospective Cohort Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522557/ https://www.ncbi.nlm.nih.gov/pubmed/33033568 http://dx.doi.org/10.4254/wjh.v12.i9.619 |
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