Cargando…

Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs

With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal...

Descripción completa

Detalles Bibliográficos
Autores principales: Philips, Cyriac Abby, Ahamed, Rizwan, Rajesh, Sasidharan, George, Tom, Mohanan, Meera, Augustine, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522561/
https://www.ncbi.nlm.nih.gov/pubmed/33033566
http://dx.doi.org/10.4254/wjh.v12.i9.574
_version_ 1783588209800773632
author Philips, Cyriac Abby
Ahamed, Rizwan
Rajesh, Sasidharan
George, Tom
Mohanan, Meera
Augustine, Philip
author_facet Philips, Cyriac Abby
Ahamed, Rizwan
Rajesh, Sasidharan
George, Tom
Mohanan, Meera
Augustine, Philip
author_sort Philips, Cyriac Abby
collection PubMed
description With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal-based preparations are devoid of toxicity, and hence short- and long-term use remain justified among people as well as the CAM practitioners who prescribe these medicines. In this regard, Ayurvedic herbal medications have become one of the most utilized in the East, specifically the Indian sub-continent, with increasing use in the West. Recent well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic drugs. Toxicity stems from direct effects or from indirect effects through herbal metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic drugs with other prescription medicines, and contamination due to poor manufacturing practices. In this exhaustive review, we present details on their hepatotoxic potential, discuss the mechanisms, clinical presentation, liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring for liver disease patients, to support early identification and treatment of those who present with CAM-induced liver injury.
format Online
Article
Text
id pubmed-7522561
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-75225612020-10-07 Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs Philips, Cyriac Abby Ahamed, Rizwan Rajesh, Sasidharan George, Tom Mohanan, Meera Augustine, Philip World J Hepatol Minireviews With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal-based preparations are devoid of toxicity, and hence short- and long-term use remain justified among people as well as the CAM practitioners who prescribe these medicines. In this regard, Ayurvedic herbal medications have become one of the most utilized in the East, specifically the Indian sub-continent, with increasing use in the West. Recent well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic drugs. Toxicity stems from direct effects or from indirect effects through herbal metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic drugs with other prescription medicines, and contamination due to poor manufacturing practices. In this exhaustive review, we present details on their hepatotoxic potential, discuss the mechanisms, clinical presentation, liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring for liver disease patients, to support early identification and treatment of those who present with CAM-induced liver injury. Baishideng Publishing Group Inc 2020-09-27 2020-09-27 /pmc/articles/PMC7522561/ /pubmed/33033566 http://dx.doi.org/10.4254/wjh.v12.i9.574 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Philips, Cyriac Abby
Ahamed, Rizwan
Rajesh, Sasidharan
George, Tom
Mohanan, Meera
Augustine, Philip
Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
title Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
title_full Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
title_fullStr Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
title_full_unstemmed Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
title_short Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
title_sort comprehensive review of hepatotoxicity associated with traditional indian ayurvedic herbs
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522561/
https://www.ncbi.nlm.nih.gov/pubmed/33033566
http://dx.doi.org/10.4254/wjh.v12.i9.574
work_keys_str_mv AT philipscyriacabby comprehensivereviewofhepatotoxicityassociatedwithtraditionalindianayurvedicherbs
AT ahamedrizwan comprehensivereviewofhepatotoxicityassociatedwithtraditionalindianayurvedicherbs
AT rajeshsasidharan comprehensivereviewofhepatotoxicityassociatedwithtraditionalindianayurvedicherbs
AT georgetom comprehensivereviewofhepatotoxicityassociatedwithtraditionalindianayurvedicherbs
AT mohananmeera comprehensivereviewofhepatotoxicityassociatedwithtraditionalindianayurvedicherbs
AT augustinephilip comprehensivereviewofhepatotoxicityassociatedwithtraditionalindianayurvedicherbs