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Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522561/ https://www.ncbi.nlm.nih.gov/pubmed/33033566 http://dx.doi.org/10.4254/wjh.v12.i9.574 |
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author | Philips, Cyriac Abby Ahamed, Rizwan Rajesh, Sasidharan George, Tom Mohanan, Meera Augustine, Philip |
author_facet | Philips, Cyriac Abby Ahamed, Rizwan Rajesh, Sasidharan George, Tom Mohanan, Meera Augustine, Philip |
author_sort | Philips, Cyriac Abby |
collection | PubMed |
description | With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal-based preparations are devoid of toxicity, and hence short- and long-term use remain justified among people as well as the CAM practitioners who prescribe these medicines. In this regard, Ayurvedic herbal medications have become one of the most utilized in the East, specifically the Indian sub-continent, with increasing use in the West. Recent well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic drugs. Toxicity stems from direct effects or from indirect effects through herbal metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic drugs with other prescription medicines, and contamination due to poor manufacturing practices. In this exhaustive review, we present details on their hepatotoxic potential, discuss the mechanisms, clinical presentation, liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring for liver disease patients, to support early identification and treatment of those who present with CAM-induced liver injury. |
format | Online Article Text |
id | pubmed-7522561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-75225612020-10-07 Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs Philips, Cyriac Abby Ahamed, Rizwan Rajesh, Sasidharan George, Tom Mohanan, Meera Augustine, Philip World J Hepatol Minireviews With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal-based preparations are devoid of toxicity, and hence short- and long-term use remain justified among people as well as the CAM practitioners who prescribe these medicines. In this regard, Ayurvedic herbal medications have become one of the most utilized in the East, specifically the Indian sub-continent, with increasing use in the West. Recent well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic drugs. Toxicity stems from direct effects or from indirect effects through herbal metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic drugs with other prescription medicines, and contamination due to poor manufacturing practices. In this exhaustive review, we present details on their hepatotoxic potential, discuss the mechanisms, clinical presentation, liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring for liver disease patients, to support early identification and treatment of those who present with CAM-induced liver injury. Baishideng Publishing Group Inc 2020-09-27 2020-09-27 /pmc/articles/PMC7522561/ /pubmed/33033566 http://dx.doi.org/10.4254/wjh.v12.i9.574 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Philips, Cyriac Abby Ahamed, Rizwan Rajesh, Sasidharan George, Tom Mohanan, Meera Augustine, Philip Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs |
title | Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs |
title_full | Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs |
title_fullStr | Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs |
title_full_unstemmed | Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs |
title_short | Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs |
title_sort | comprehensive review of hepatotoxicity associated with traditional indian ayurvedic herbs |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522561/ https://www.ncbi.nlm.nih.gov/pubmed/33033566 http://dx.doi.org/10.4254/wjh.v12.i9.574 |
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