The Multifaceted Roles of RCC1 in Tumorigenesis

RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a series of cell physiological activities. In this r...

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Detalles Bibliográficos
Autores principales: Ren, Xuanqi, Jiang, Kai, Zhang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522611/
https://www.ncbi.nlm.nih.gov/pubmed/33102517
http://dx.doi.org/10.3389/fmolb.2020.00225
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author Ren, Xuanqi
Jiang, Kai
Zhang, Feng
author_facet Ren, Xuanqi
Jiang, Kai
Zhang, Feng
author_sort Ren, Xuanqi
collection PubMed
description RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a series of cell physiological activities. In this review, we discuss the structure of RCC1 and describe how RCC1 affects the formation and function of the nuclear envelope, spindle formation, and nuclear transport. We mainly focus on the effect of RCC1 on the cell cycle during tumorigenesis and the recent research progress that has been made in relation to different tumor types.
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spelling pubmed-75226112020-10-22 The Multifaceted Roles of RCC1 in Tumorigenesis Ren, Xuanqi Jiang, Kai Zhang, Feng Front Mol Biosci Molecular Biosciences RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a series of cell physiological activities. In this review, we discuss the structure of RCC1 and describe how RCC1 affects the formation and function of the nuclear envelope, spindle formation, and nuclear transport. We mainly focus on the effect of RCC1 on the cell cycle during tumorigenesis and the recent research progress that has been made in relation to different tumor types. Frontiers Media S.A. 2020-09-15 /pmc/articles/PMC7522611/ /pubmed/33102517 http://dx.doi.org/10.3389/fmolb.2020.00225 Text en Copyright © 2020 Ren, Jiang, Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Ren, Xuanqi
Jiang, Kai
Zhang, Feng
The Multifaceted Roles of RCC1 in Tumorigenesis
title The Multifaceted Roles of RCC1 in Tumorigenesis
title_full The Multifaceted Roles of RCC1 in Tumorigenesis
title_fullStr The Multifaceted Roles of RCC1 in Tumorigenesis
title_full_unstemmed The Multifaceted Roles of RCC1 in Tumorigenesis
title_short The Multifaceted Roles of RCC1 in Tumorigenesis
title_sort multifaceted roles of rcc1 in tumorigenesis
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522611/
https://www.ncbi.nlm.nih.gov/pubmed/33102517
http://dx.doi.org/10.3389/fmolb.2020.00225
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