Differential epigenetic regulation between the alternative promoters, PRDM1α and PRDM1β, of the tumour suppressor gene PRDM1 in human multiple myeloma cells

Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant plasma cells in the bone marrow. The transcription factor PRDM1 is a master regulator of plasma cell development and is considered to be an oncosuppressor in several lymphoid neoplasms. The PRDM1β isofo...

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Detalles Bibliográficos
Autores principales: Romero-García, Raquel, Gómez-Jaramillo, Laura, Mateos, Rosa María, Jiménez-Gómez, Gema, Pedreño-Horrillo, Nuria, Foncubierta, Esther, Rodríguez-Gutiérrez, Juan Francisco, Garzón, Sebastián, Mora-López, Francisco, Rodríguez, Carmen, Valor, Luis M., Campos-Caro, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522722/
https://www.ncbi.nlm.nih.gov/pubmed/32985591
http://dx.doi.org/10.1038/s41598-020-72946-z

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