Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity

The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that germline MALT1 protease inactivation in mice results in reduced regulator...

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Detalles Bibliográficos
Autores principales: Demeyer, Annelies, Driege, Yasmine, Skordos, Ioannis, Coudenys, Julie, Lemeire, Kelly, Elewaut, Dirk, Staal, Jens, Beyaert, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522757/
https://www.ncbi.nlm.nih.gov/pubmed/33083726
http://dx.doi.org/10.1016/j.isci.2020.101557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522757/
https://www.ncbi.nlm.nih.gov/pubmed/33083726
http://dx.doi.org/10.1016/j.isci.2020.101557

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