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Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that germline MALT1 protease inactivation in mice results in reduced regulator...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522757/ https://www.ncbi.nlm.nih.gov/pubmed/33083726 http://dx.doi.org/10.1016/j.isci.2020.101557 |